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Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Copyright (c) 2026 Gopi Chandravadivelu, Magharla Dasaratha Dhanaraju, Eethakota Parimala Naga Devi, Irpa Supriya, Gullapudi Durga Pravallika

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Exploration of Novel Thiazole Scaffolds with Potential Therapeutic Applications

https://doi.org/10.14233/ajchem.2026.36430
Chandravadivelu Gopi
Department of Pharmaceutical Chemistry, School of Pharmacy, Godavari Global University, Rajamahendravaram-533296, India
https://orcid.org/0000-0001-7382-5474
Magharla Dasaratha Dhanaraju
Research Lab, School of Pharmacy, Godavari Global University, Rajamahendravaram-533296, India
https://orcid.org/0000-0003-4876-7051
Eethakota Parimala Naga Devi
Department of Pharmaceutical Chemistry, School of Pharmacy, Godavari Global University, Rajamahendravaram-533296, India
https://orcid.org/0009-0007-3672-7497
Irpa Supriya
Department of Pharmaceutical Chemistry, School of Pharmacy, Godavari Global University, Rajamahendravaram-533296, India
https://orcid.org/0009-0009-0231-6379
Gullapudi Durga Pravallika
Department of Pharmaceutical Chemistry, School of Pharmacy, Godavari Global University, Rajamahendravaram-533296, India
https://orcid.org/0009-0007-3873-9264

Corresponding Author(s) : Chandravadivelu Gopi

gopic@ggu.edu.in

Asian Journal of Chemistry, Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Abstract

This study focuses on the synthesis and evaluation of the antimicrobial, anti-inflammatory and antipyretic activities of novel thiazole-based Schiff base derivatives (S1-S6). The compounds were synthesized through condensation reactions between 2-aminothiazole and several aromatic aldehydes. Structural characterization of the synthesized derivatives was carried out using FTIR, 13C NMR, 1H NMR, mass spectrometry techniques and elemental analysis. Initially, thiazole-based Schiff base derivatives therapeutic activities were assessed from AutoDock score after the successful binding with Staphylococcus aureus DNA gyrase B and cyclooxygenase 2. The synthesized derivatives were also evaluated for antimicrobial, anti-inflammatory and antipyretic activities using in vitro and in vivo methods. Compounds S6 and S1 showed the highest activity, possibly due to the thiazole nucleus linked to furan and substituted aromatic rings. The experimental findings were consistent with the in silico molecular docking results.

Keywords

Thiazole Schiff base derivatives Antimicrobial activity Anti-inflammatory activity Anti-pyretic activity
(1)
Gopi, C.; Dhanaraju, M. D.; Naga Devi, E. P.; Supriya, I.; Pravallika, G. D. Exploration of Novel Thiazole Scaffolds With Potential Therapeutic Applications. ajc 2026, 38, 2485-2491.
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