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Vol. 31 No. 8 (2019): Vol 31 Issue 8

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Structure Activity Relationship, Drug Likeness and Evaluation of Antioxidant Activity of Some Mannich Bases of Dihydropyrimidinones

https://doi.org/10.14233/ajchem.2019.22008
Ravinder Mamidala
Department of Medicinal Chemistry, St. Peter's Institute of Pharmaceutical Sciences, Warangal-506001, India
Solomon Raj S. Bhimathati
Department of Pharmacology, Siddhartha Institute of Pharmacy, Narapally, Ghatkesar, Hyderabad-501301, India
Aparna Vema
Department of Pharmaceutical Chemistry, College of Pharmacy, K L University, Vaddeswaram-520002, India

Corresponding Author(s) : Ravinder Mamidala

mamidalapharmacy@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 8 (2019): Vol 31 Issue 8

Abstract

A series of 21 O- and N-Mannich bases of 3,4-dihydropyrimidinones (2a-j and 3a-k) were synthesized by using microwave irradiation technique by multi-component reaction in two steps. All the compounds were evaluated for their free radical scavenging activity by four methods. Structure activity relationship studies revealed that the compounds 2h, 2g, 3h and 3g exhibited profound antioxidant properties compared to standard ascorbic acid. Among O- and N-Mannich bases, N-Mannich bases were found to be more potent in scavenging free radicals. The correlation between structure and activities of these compounds with concern to drug likeliness profile and other physico-chemical parameters are portrayed and verified experimentally.

Keywords

Antioxidant activity Dihydropyrimidinones Drug likeness Mannich bases Structure activity relationship
Mamidala, R., S. Bhimathati, S. R., & Vema, A. (2019). Structure Activity Relationship, Drug Likeness and Evaluation of Antioxidant Activity of Some Mannich Bases of Dihydropyrimidinones. Asian Journal of Chemistry, 31(8), 1767–1773. https://doi.org/10.14233/ajchem.2019.22008
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