Synthesis, Characterisation and Microbial Activity of  Melia azedarach Encapsulated ZIF-8 Metal-Organic Frameworks

Raju Potnuru; Gopi Mamidi; Tirumala Santhoshkumar Saripalli; Mary Shamya Arokiarajan; Achintya Kumar Mandal

doi:10.14233/ajchem.2026.36362

Issue

Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Issue Published : 7 August 2026

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterisation and Microbial Activity of Melia azedarach Encapsulated ZIF-8 Metal-Organic Frameworks

https://doi.org/10.14233/ajchem.2026.36362

Raju Potnuru

Department of Chemistry, V.S. Krishna Government Degree and P.G. College (Affiliated to Andhra University), Visakhapatnam-530013, India; Department of Chemistry, M.R. College (Autonomous), Vizianagaram-535002, India

https://orcid.org/0009-0000-0127-6197

Gopi Mamidi

Department of Chemistry, V.S. Krishna Government Degree and P.G. College (Affiliated to Andhra University), Visakhapatnam-530013, India

https://orcid.org/0009-0008-8003-840X

Tirumala Santhoshkumar Saripalli

Regional Research Institute of Unani Medicine, Chennai-600013, India

https://orcid.org/0000-0003-1259-8671

Mary Shamya Arokiarajan

Regional Research Institute of Unani Medicine, Chennai-600013, India

https://orcid.org/0000-0002-2900-1475

Achintya Kumar Mandal

Regional Research Institute of Unani Medicine, Chennai-600013, India

https://orcid.org/0000-0003-4967-2310

Corresponding Author(s) : Gopi Mamidi

drgopichem@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)
Article Published : 7 August 2026

Abstract

Zeolite imidazolate frameworks-8 (ZIF-8) is one of the most widely studied metal-organic frameworks (MOFs) due of its high stability, large surface area and excellent gas separation performance. This study reports the encapsulation of the Melia azedarach L. extract (MAZ) into zeolitic imidazolate framework-8 (ZIF-8) through a simple nanoprecipitation method. The resulting MAZ@ZIF-8 nanocomposite was characterized by powder X-ray diffraction (PXRD), Fourier-transform infrared (FT-IR) spectroscopy, and dynamic light scattering (DLS). The nanocomposite exhibited good structural stability, remaining stable for at least 25 days, indicating its suitability as a robust functional material. The antimicrobial activities of MAZ, ZIF-8 and MAZ@ZIF-8 were evaluated and compared. The enhanced stability and biological activity of MAZ@ZIF-8 suggest its potential for a wide range of biomedical and antimicrobial applications.

Keywords

ZIF-8 Melia azedarach. L Metal organic frameworks Nanocomposites P-XRD

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Potnuru, R.; Mamidi, G.; Saripalli, T. S.; Arokiarajan, M. S.; Mandal, A. K. Synthesis, Characterisation and Microbial Activity of Melia Azedarach Encapsulated ZIF-8 Metal-Organic Frameworks. ajc 2026, 38, 2177-2182.

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N. Vijendra and K.P. Kumar, Afr. J. Pharm. Pharmacol., 4, 662 (2010).

M.C. Corpinella, M. Miranda, W.R. Almiron, C.G. Ferrayoli, F.L. Almeida and S.M. Palacios, J. Am. Acad. Dermatol., 56, 250 (2007); https://doi.org/10.1016/j.jaad.2006.10.027

C.B. Wandscheer, J.E. Duque, M.A.N. da Silva, Y. Fukuyama, J.L. Wohlke, J. Adelmann and J.D. Fontana, Toxicon, 44, 829 (2004); https://doi.org/10.1016/j.toxicon.2004.07.009

M.A. Neycee, G.H.A. Nematzadeh, A. Dehestani and M. Alavi, Int. J. Agric. Crop Sci., 4, 709 (2012).

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N. Morsy, Main Group Chem., 13, 7 (2014); https://doi.org/10.3233/MGC-130117

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M. Kancherla, R. Meena and M.Y. Dar, J. Herb. Med., 42, 100812 (2023); https://doi.org/10.1016/j.hermed.2023.100812

B. Singh, D. Pandya and A. Mankad, J. Plant Sci. Res., 36, 53 (2020).

R. Potnuru, G. Mamidi, T. S. Saripalli, M.S. Arokiarajan, J. Christopher, A.K. Mandal and M. Jameel, Discover Nano, 20, 192 (2025); https://doi.org/10.1186/s11671-025-04377-6

N.S. Kumar, M.S. Reddy, T.S. Kumar, V.R. Bheeram, S.B. Mukkamala and L. Chandrasekhara Rao, ChemistrySelect, 4, 1188 (2019); https://doi.org/10.1002/slct.201803302

H. Yu, S.S. Muhammad, H. Murtaza, Z. Ayesha, Z. Xi, W. Muhammad, T. Tuba, X. Huang and H. Riaz, ACS Omega, 8, 48535 (2023); https://doi.org/10.1021/acsomega.3c08494

J. Bankuru, V.R. Battula, T.S. Santhoshkumar, S. Gopal, R.P. Meena and N.Z. Ahmed, JCIS Open, 12, 100097 (2023); https://doi.org/10.1016/j.jciso.2023.100097

X. Meng, K. Jia, K. Sun, L. Zhang and Z. Wang, Chem. Eng. J., 415, 128947 (2021); https://doi.org/10.1016/j.cej.2021.128947

Author biographies is not available.