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Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Copyright (c) 2026 Parmeshwar Vishnu Bankar Bankar Family, Dr. Mahesh G. Shioorkar

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TiO2-Catalysed Synthesis of Hydrazinyl Thiazoles and their Evaluation for Anticancer Activity in MOC2 Cells

https://doi.org/10.14233/ajchem.2026.36028
P.V. Bankar
Department of Chemistry, Bhawabhuti Mahavidyalaya, Amgaon-441902, India
https://orcid.org/0009-0002-0405-8237
O.S. Chavan
Department of Chemistry, Badrinarayan Barwale Mahavidyalaya, Jalna-431203, India
https://orcid.org/0009-0008-7432-7096
D.S. Jadhav
Department of Chemistry, Vivekanand Arts, Sardar Dalipsingh Commerce & Science College, Samarthnagar, Chhatrapati Sambhajinagar- 431001, India
https://orcid.org/0009-0002-8076-1899
P. Vipparthi
Department of Pharmacy, Birla Institute for Technology & Science, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District-500078, India
https://orcid.org/0009-0000-6329-8236
M.G. Shioorkar
Department of Chemistry, Vivekanand Arts, Sardar Dalipsingh Commerce and Science College, Chhatrapati Sambhajinagar-431001, India
https://orcid.org/0000-0002-5869-6317

Corresponding Author(s) : M.G. Shioorkar

shioorkar@vivekanandcollege.edu.in

Asian Journal of Chemistry, Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Abstract

A series of hydrazinyl thiazole derivatives were synthesised (4a-j) via an efficient titanium dioxide (TiO2) catalysed protocol using 1-indanone, phenacyl bromide and thiosemicarbazide as key starting materials. All the synthesised compounds were fully characterised by 1H NMR, 13C NMR and mass spectral data. The developed methodology offers mild reaction conditions, good to excellent yield and operational simplicity, highlighting the catalytic efficiency of TiO2. The synthesized compounds were also evaluated against MOC2 cell lines using the MTT assay as a preliminary in vitro screening tool to assess their anticancer activity, effects on cell viability, comparative efficacy, and structure–activity relationships. The obtained results were expressed with IC50 µM and 4f was the most potent with an IC50 of 26.53 µM, followed by 4d (30.48 µM) and 4h (37.83 µM).

Keywords

Hydrazinyl thiazole derivatives 1-Indanone Anticancer activity Phenacyl bromide Thiosemicarbazide
(1)
Bankar, P.; Chavan, O.; Jadhav, D.; Vipparthi, P.; Shioorkar, M. TiO2-Catalysed Synthesis of Hydrazinyl Thiazoles and Their Evaluation for Anticancer Activity in MOC2 Cells. ajc 2026, 38, 1768-1774.
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