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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 GAVALI LAXMAN

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Microwave-Assisted Synthesis and Antimicrobial Profiling of New Pyrrolo-Pyrimidine Analogues

https://doi.org/10.14233/ajchem.2023.28100
GAVALI LAXMAN
Chem Research Lab, Karmveer Bhaurao Patil College, Vashi, Navi Mumbai-400703, India
https://orcid.org/0000-0001-9083-7311
HANDE BHAUSAHEB
Chem Research Lab, Karmveer Bhaurao Patil College, Vashi, Navi Mumbai-400703, India
https://orcid.org/0009-0008-0983-5115

Corresponding Author(s) : GAVALI LAXMAN

laxmanvg70@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

Present study intended for the development of microbial resistance of existing antimicrobials to synthesize some new antimicrobials. This study involved a microwave assisted synthesis of some new 4-aminopyrrolo[2,3-d]pyrimidine analogues (2a-h), which were synthesized via condensation of substituted benzaldehydes and 4-aminopyrrolo[2,3-d]pyrimidine. All the compounds were characterized (using elemental analysis and IR, 1H NMR spectrometry) and evaluated for their antibacterial (against S. aureus, B. subtilis, E. coli and P. aeruginosa) and antifungal (against C. albicans and S. cerevisiae) potential by determining the zone of inhibition using disk diffusion method. The antibacterial activity of compounds 2a-h revealed that compounds 2c, 2e and 2f against E. coli, 2d against S. aureus, 2f against B. subtilis and 2d against P. aeruginosa exhibited maximum inhibitory activity. Whereas antifungal activity of compounds 2a-h revealed that compound 2g (against C. albicans) and 2b and 2e (against S. cerevisiae) exhibited maximum antimicrobial activity (zone of inhibition). The high antibacterial and antifungal potential of newly synthesized compounds supports their potential application as antibacterial and antifungal agents, however the synthesized compounds must be additionally investigated for the in vivo and clinical studies.

Keywords

4-Aminopyrrolo[2,3-d]pyrimidine Substituted benzaldehydes Antibacterial activity Antifungal activity
LAXMAN, G., & BHAUSAHEB, H. (2023). Microwave-Assisted Synthesis and Antimicrobial Profiling of New Pyrrolo-Pyrimidine Analogues. Asian Journal of Chemistry, 35(9), 2210–2214. https://doi.org/10.14233/ajchem.2023.28100
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