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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 Rajrani Gulia, Dr. Vikas Sangwan, Dr. Anshul Singh

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Spectral Characterization and Biological Evaluation of Glutaric acid based Macrocyclic Complexes

https://doi.org/10.14233/ajchem.2023.28087
Rajrani Gulia
Department of Chemistry, Baba Mastnath University, Rohtak-124021, India
Dr. Vikas Sangwan
Department of Chemistry, R.P.S. Degree College, Mahendergarh-123029, India
https://orcid.org/0000-0003-2583-3562
Dr. Anshul Singh
Department of Chemistry, Baba Mastnath University, Rohtak-124021, India
https://orcid.org/0000-0003-0962-308X

Corresponding Author(s) : Dr. Anshul Singh

anshul9008@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

In the presence of divalent transition metal ions in their chloride forms, glutaric acid and o-phenylenediamine were used to design and synthesize a unique series of macrocyclic complexes. The UV-Visible, IR, ESR, and ESI-MS spectroscopy methods were used to analyze these newly designed complexes. In order to evaluate their thermal behavior, TGA analysis was employed. The intended general formula for the produced complexes was [M(L)X2] (L = ligand, X = Cl- and M = Co2+, Ni2+ and Cu2+). The central metal ions are  surrounded by octahedral environment. These macrocyclic complexes were tested for their antimicrobial effectiveness against the  selected bacterial strains (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli), as well as fungi strains  (Aspergillus niger and Candida albicans) and their efficacy was compared to that of standard drugs Streptomycin and Itraconazole respectively. Moreover, the antioxidant activity of the macrocyclic complexes were also assessed using the DPPH assay. 

Keywords

Antifungal Antibacterial Glutaric acid Tetraaza macrocyclic complexes DPPH assay
Rajrani gulia, R. G., Vikas Sangwan, V. S., & Anshul, A. S. (2023). Synthesis, Spectral Characterization and Biological Evaluation of Glutaric acid based Macrocyclic Complexes. Asian Journal of Chemistry, 35(9), 2125–2130. https://doi.org/10.14233/ajchem.2023.28087
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