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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 KEERTHISIKHA PALUR

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Development and Validation of Chemometric Assisted UV Spectroscopic Methods for the Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Marketed Formulation

https://doi.org/10.14233/ajchem.2023.28077
KEERTHISIKHA PALUR
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
https://orcid.org/0000-0002-1121-0391
SREENIVASA CHARAN ARCHAKAM
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
https://orcid.org/0000-0001-9057-9754
PRIYANKA PATAKAM
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
KAVYA ORUPALLI
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
PADMAJA YADAVALI
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
YOGESWAR POTHAPALA
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India
RANGANAYAKULU DIVITI
Department of Pharmaceutical Analysis, Sri Padmavathi School of Pharmacy, Mohan Gardens, Tiruchanoor-517503, India

Corresponding Author(s) : KEERTHISIKHA PALUR

keerthi8spsp@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

The present work discusses the development and validation of chemometric assisted UV spectroscopic methods for analyzing two  drugs amitriptyline hydrochloride and propranolol hydrochloride in their marketed formulation. The developed methods are two  prominent chemometric models namely, principal component regression (PCR) and partial least squares regression (PLS) on which  several research articles have been published for their immense contribution in the quantification of multi-component formulations.  Linearity of the UV spectroscopic method was in the concentration ranges of 3-15 μg/mL of amitriptyline hydrochloride and 5-45 μg/mL of propranolol hydrochloride. The PCR and PLS chemometric models were established by employing fourteen mixtures as a calibration set and five mixtures as a validation set and were executed in the wavelength range of 240-320 nm with data interval of 5 nm. The  statistical parameters obtained from both the methods revealed their validity and hence allows their suitability for analysis in regular  quality control laboratories. 

Keywords

Chemometrics Principal component regression Partial least squares regression Amitriptyline Propranolol
PALUR, K., CHARAN ARCHAKAM, S., PATAKAM, P., ORUPALLI, K., YADAVALI, P., POTHAPALA, Y., & DIVITI, R. (2023). Development and Validation of Chemometric Assisted UV Spectroscopic Methods for the Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Marketed Formulation. Asian Journal of Chemistry, 35(9), 2121–2124. https://doi.org/10.14233/ajchem.2023.28077
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