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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 Dishank Purandare, PRAJAKTA ADSULE

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Synthesis and Evaluation of Analgesic and Antioxidant Activity of 3-Phenyl Coumarin Derivatives

https://doi.org/10.14233/ajchem.2023.28059
PRAJAKTA ADSULE
School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune- 411038, India
https://orcid.org/0000-0001-8009-2731
Dishank Purandare
School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune- 411038, India
https://orcid.org/0009-0001-2822-700X
S. KULKARNI
School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune- 411038, India
https://orcid.org/0009-0009-5129-5789
R. JOSHI
School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune- 411038, India
https://orcid.org/0009-0003-0889-917X
A. CHABUKSWAR
School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune- 411038, India
https://orcid.org/0000-0002-2868-6652

Corresponding Author(s) : PRAJAKTA ADSULE

prajakta.adsule81@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

A series of 3- phenyl substituted coumarin derivatives prepared by reacting substituted aromatic aldehyde with phenylacetic acid. The chemical composition of substituted coumarin derivatives was confirmed by FT-IR, 1H NMR spectra and elemental analysis. Designed 3-phenyl coumarin derivatives were docked with Cyclooxygenase-2 (COX-2) enzyme (PDB CODE: 3Q7D). Compounds were synthesized and evaluated for in-vivo analgesic and in-vitro antioxidant activities depending upon the highest binding affinity. Compounds 02, 10, and 11 exhibited significant analgesic activity. Compounds 09, 04, 01, and 03   showed significant antioxidant potential in the DPPH  method, and Compounds 05 and 07 have shown excellent scavenging potential in the nitric oxide scavenging method compared to  ascorbic acid. This research work includes the synthesis of 3-phenyl coumarin scaffolds and the evaluation of their analgesic &  antioxidant activity.

Keywords

3-Phenyl coumarin Molecular docking Analgesic activity Antioxidant activity
ADSULE, P., Purandare, D., KULKARNI, S., JOSHI, R., & CHABUKSWAR, A. (2023). Synthesis and Evaluation of Analgesic and Antioxidant Activity of 3-Phenyl Coumarin Derivatives. Asian Journal of Chemistry, 35(9), 2109–2114. https://doi.org/10.14233/ajchem.2023.28059
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