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Vol. 35 No. 8 (2023): Vol 35 Issue 8, 2023

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Synthesis, Characterization and Biological Evaluation of Novel Methoxy Benzaldehyde Substituted Derivatives of Pyrazolopyrimidine-4-hydrazide

https://doi.org/10.14233/ajchem.2023.27908
Rubeena Mansuri
Department of Chemistry, Pacific University of Higher Education and Research, Udaipur-313003, India
https://orcid.org/0009-0007-4948-165X
Raj Badekar
R&D Department, RIVA Industries, Ambernath MIDC, Ambernath West, Thane-421505, India
https://orcid.org/0000-0002-9425-4743
Priyanka Jhalora
Department of Chemistry, Pacific University of Higher Education and Research, Udaipur-313003, India
https://orcid.org/0000-0003-2139-8428

Corresponding Author(s) : Rubeena Mansuri

rubeena2711@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 8 (2023): Vol 35 Issue 8, 2023

Abstract

Several novel pyrrolopyrimidine derivatives of methoxybenzaldehydes with biologically active pyrrole moieties were synthesized to investigate their antibacterial, antifungal and cytotoxic activities. Elemental analysis, UV-spectra, FT-IR, 1H NMR and 13C NMR spectra, were used to characterize the synthesized compounds. The in vitro antifungal and antibacterial activities were tested for all the synthesized compounds. Compared to the reference drugs e.g. fluconazole and streptomycin, most of the compounds tested positive for antifungal and antibacterial activity. All tested compounds demonstrated superior cytotoxic activity to the reference drug doxorubicin, with IC50 values ranging from 6.52 to 7.77 mM and comparable activity with IC50 values of 8.21 and 8.27 mM, respectively. In vitro antibacterial and antifungal activities revealed that the compouds b and e were more effective than the standard drugs streptomycin and fluconazole, respectively.

Keywords

Methoxybenzaldehydes 4-Aminopyrrolo[2,3-d]pyrimidine Dimethoxyaldehydes 4-Hydroxy-3-methoxybenzaldehyde
Mansuri, R., Badekar, R., & Jhalora, P. (2023). Synthesis, Characterization and Biological Evaluation of Novel Methoxy Benzaldehyde Substituted Derivatives of Pyrazolopyrimidine-4-hydrazide. Asian Journal of Chemistry, 35(8), 1921–1926. https://doi.org/10.14233/ajchem.2023.27908
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