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Vol. 35 No. 7 (2023): Vol 35 Issue 7 (2023)

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Exploration of in vitro Antioxidant and Cytotoxic Activities of Whole Plant Extracts of Rhynchosia heynei Wight & Arn: An Endemic Medicinal Herbaceous Under Shrub of Eastern Ghats of India

https://doi.org/10.14233/ajchem.2023.27955
Nirmala Korukola
Department of Pharmacognosy, K.G.R.L. College of Pharmacy, Dirusumarru Road, Bhimavaram-534201, India
https://orcid.org/0009-0004-1605-1184
Girija Sastry Vedula
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
https://orcid.org/0000-0001-6250-8473
Mohan Gandhi Bonthu
Department of Pharmaceutical Analysis, V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521356, India
https://orcid.org/0000-0002-3559-2312
Lakshmana Rao Atmakuri
Department of Pharmaceutical Analysis, V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521356, India
https://orcid.org/0000-0001-5601-037X

Corresponding Author(s) : Nirmala Korukola

nirmalakorukola@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 7 (2023): Vol 35 Issue 7 (2023)

Abstract

This study reports the antioxidant and anticancer potential of Rhynchosia heynei, a widely used plant in traditional medicine, against various cancerous cell lines. The study found that R. heynei exhibited significant radical scavenging activity, indicating its potential as a natural antioxidant compound to guard against oxidative stress-induced diseases, including cancer. The plant extracts also displayed selective cytotoxicity towards various cell lines, with the most potent cytotoxicity exhibited by the ethanol extract towards the MCF-7 cell line and diethyl ether extract towards the HCT-116 cell line. The hexane extract exhibited substantial cytotoxic activity against HepG2, HCT-116 and L6 cell lines. However, the aqueous extract of R. heynei was the least cytotoxic of all the cell lines employed. Overall, the cytotoxic activity of R. heynei extracts was majorly selective towards MCF-7 and HCT-116. The findings suggest that R. heynei could be a potent natural product for developing anticancer drugs with fewer side effects. Further, in vitro and in vivo studies are required to determine the exact mechanism of action of the plant’s potential anticancer activity.

Keywords

Rhynchosia heynei Antioxidant Anticancer Selective cytotoxicity SRB assay Natural compounds Phytochemicals
Korukola, N., Vedula, G. S., Bonthu, M. G., & Atmakuri, L. R. (2023). Exploration of in vitro Antioxidant and Cytotoxic Activities of Whole Plant Extracts of Rhynchosia heynei Wight & Arn: An Endemic Medicinal Herbaceous Under Shrub of Eastern Ghats of India. Asian Journal of Chemistry, 35(7), 1702–1706. https://doi.org/10.14233/ajchem.2023.27955
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