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Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

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Bioactive Flavonol C-Glycoside from Sida cordifolia L. and its Molecular Docking Study

https://doi.org/10.14233/ajchem.2023.27636
Md. Din Islam
Faculty of Engineering and Technology, Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0003-4652-8081
Shyama Prasad Mitra
Chattogram Cantonment Public College, Chattogram, Bangladesh
https://orcid.org/0000-0002-9201-5490
Saswata Rabi
Faculty of Engineering and Technology, Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0001-5911-1184
Emdad Hossain
Wazed Miah Science Research Center, Jahangirnagar University, Savar, Dhaka, Bangladesh
https://orcid.org/0000-0003-1398-2851
Ranajit Kumar Sutradhar
Faculty of Engineering and Technology, Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0002-6020-0528

Corresponding Author(s) : Ranajit Kumar Sutradhar

rksutradhar2002@yahoo.com

Asian Journal of Chemistry, Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

Abstract

Phytochemical studies of the aerial parts of Sida cordifolia L. has led to the isolation of a new flavonol C-glycoside, 3′-(3′′,7′′-dimethyl-2′′,6′′-octadiene)-8-C-β-D-glucosyl-kaempferol-3-O-β-D-galactoside (1) together with two known flavonoids, luteolin and quercetin. The structures of all the compounds were established on the basis of chemical and spectroscopic studies. Compound 1 was assessed to check the analgesic and anti-inflammatory activities and showed significant activities. Molecular docking study was conducted for compound 1 against 4O1Z protein receptor, which strongly support the in vitro biological findings.

Keywords

Sida cordifolia Malvaceae Flavonol C-glycoside Bioactivity Molecular docking
Islam, M. D., Mitra, S. P., Rabi, S., Hossain, E., & Sutradhar, R. K. (2023). Bioactive Flavonol C-Glycoside from Sida cordifolia L. and its Molecular Docking Study. Asian Journal of Chemistry, 35(6), 1429–1433. https://doi.org/10.14233/ajchem.2023.27636
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