Issue

Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Development of Nano-Hydroxyapatite Polymer Composite and it's in vitro Activity for Biomedical Applications

https://doi.org/10.14233/ajchem.2023.27741
S. Mary Stella
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India
U. Vijayalakshmi
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India
https://orcid.org/0000-0003-0727-4277

Corresponding Author(s) : U. Vijayalakshmi

lakesminat@yahoo.com

Asian Journal of Chemistry, Vol. 35 No. 6 (2023): Vol 35 Issue 6, 2023

Abstract

In present work, the composites of hydroxyapatite with polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) were prepared and analyzed for its biodegradability and hemocompatibilty. The individual and the combined combination of polymers with hydroxyapatite (HAP-PVA, HAP-PVP and HAP/PVA-PVP) were characterized by FT-IR, XRD, SEM-EDAX and TGA-DSC analysis. The crystallinity and functional groups of hydroxyapatite (HAP) was confirmed by XRD and FT-IR analysis. The SEM analysis displayed rod shaped morphology and the formation of apatite layer was confirmed by simulated body fluid (SBF) immersion. The Ca/P ratio of the SBF immersed composite was found to be increased to 1.71. This reveals that the polymer in the composite acts as a nucleating site for the development of carbonated hydroxyapatite which chemical composition resembles with natural bone. The hemolysis rate for the composite consisting of HAP/PVA-PVP was found to be less than 3% than the composite consisting of HAP with PVP. Based on these results, it can be concluded that the HAP/PVA-PVP nanocomposite offers superior alternatives in the field of biomedicines.

Keywords

Biocompatibility Hemocompatibility Hydroxyapatite Nanocomposite Polymers
Stella, S. M., & Vijayalakshmi, U. (2023). Development of Nano-Hydroxyapatite Polymer Composite and it’s in vitro Activity for Biomedical Applications. Asian Journal of Chemistry, 35(6), 1361–1368. https://doi.org/10.14233/ajchem.2023.27741
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. R.Y. Basha, S.K. Sampath and M. Doble, Mater. Sci. Eng. C, 57, 452 (2011); https://doi.org/10.1016/j.msec.2015.07.016
  2. S.M. Stella, T.M. Sridhar, R. Ramprasath, J. Gimbun and U. Vijayalakshmi, Polymers, 15, 155 (2022); https://doi.org/10.3390/polym15010155
  3. B. Dhandayuthapani, Y. Yoshida, T. Maekawa and and D.S. Kumar, Int. J. Polym. Sci., 2011, 290602 (2011); https://doi.org/10.1155/2011/290602
  4. S.U. Maheshwari, V.K. Samuel and N. Nagiah, Ceram. Int., 40, 8469 (2014); https://doi.org/10.1016/j.ceramint.2014.01.058
  5. N. Ramesh, S.C. Moratti and G.J. Dias, J. Biomed. Mater. Res. B Appl. Biomater., 106, 2046 (2018); https://doi.org/10.1002/jbm.b.33950
  6. S.M. Stella and U. Vijayalakshmi, J. Biomed. Mater. Res. A, 107, 610 (2019); https://doi.org/10.1002/jbm.a.36577
  7. A. Asti and L. Gioglio, Int. J. Artif. Organs, 37, 187 (2014); https://doi.org/10.5301/ijao.5000307
  8. J.M. Dodda, P. Bìlský, J. Chmelaø, T. Remiš, K. Smolná, M. Tomáš, L. Kullová and J. Kadlec, J. Mater. Sci., 50, 6477 (2015); https://doi.org/10.1007/s10853-015-9206-7
  9. M.A.-F. Basha, Polym. J., 42, 728 (2010); https://doi.org/10.1038/pj.2010.60
  10. C.A. Charitidis, A. Skarmoutsou, A. Tsetsekou, D. Brasinika and D. Tsiourvas, Mater. Sci. Eng. B, 178, 391 (2013); https://doi.org/10.1016/j.mseb.2013.01.002
  11. M. Navarro, A. Michiardi, O. Castaño and J.A. Planell, J. R. Soc. Interface, 5, 1137 (2008); https://doi.org/10.1098/rsif.2008.0151
  12. H. Oudadesse, Y.L. Gal, O. Merdrignac-Conanec, G. Cathelineau and X.V. Bui, Korean J. Chem. Eng., 29, 215 (2012); https://doi.org/10.1007/s11814-011-0151-0
  13. A. Mostafa, H. Oudadesse, M.B. Mohamed, E.S. Foad, Y. Le Gal and G. Cathelineau, Chem. Eng. J., 153, 187 (2009); https://doi.org/10.1016/j.cej.2009.05.039
  14. T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro, J. Biomed. Mater. Res., 24, 721 (1990); https://doi.org/10.1002/jbm.820240607
  15. C.H. Yeo, S.H.S. Zein, A.L. Ahmad and D.S. McPhail, Braz. J. Chem. Eng., 29, 147 (2012); https://doi.org/10.1590/S0104-66322012000100016
  16. A.F. Leitão, S. Gupta, J.P. Silva, I. Reviakine and M. Gama, Colloids Surf. B Biointerfaces, 111, 493 (2013); https://doi.org/10.1016/j.colsurfb.2013.06.031
  17. N. Krishnamacharyulu, G. Jagan Mohini, G. Sahaya Baskaran, V. Ravi Kumar and N. Veeraiah, J. Alloys Compd., 734, 318 (2018); https://doi.org/10.1016/j.jallcom.2017.10.271
  18. M. Rama and U. Vijayalakshmi, J. Drug Deliv. Sci. Technol., 61, 102182 (2021); https://doi.org/10.1016/j.jddst.2020.102182
  19. C. Guo, L. Zhou and J. Lv, Polym. Polymer Compos., 21, 449 (2013); https://doi.org/10.1177/096739111302100706
  20. J. Rodríguez, E. Navarrete, E.A. Dalchiele, L. Sánchez, J.R. Ramos-Barrado and F. Martín, J. Power Sources, 237, 270 (2013); https://doi.org/10.1016/j.jpowsour.2013.03.043
  21. M.B. El-Arnaouty, M. Eid, M. Salah and E.-S.A. Hegazy, J. Macromol. Sci. Part A Pure Appl. Chem., 49, 1041 (2012); https://doi.org/10.1080/10601325.2012.728466
  22. B. Priyadarshini and U. Vijayalakshmi, Mater. Sci. Eng. C, 119, 111620 (2021); https://doi.org/10.1016/j.msec.2020.111620
  23. Chetan and U. Vijayalakshmi, J. Biomed. Mater. Res. B Appl. Biomater., 108, 3286 (2020); https://doi.org/10.1002/jbm.b.34665
Read More
Author biographies is not available.
Download
AJC-35-6-10
Statistic
Read Counter : 0 Download : 0