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Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

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Synthesis, in silico Biological Profile and MMP-9 Inhibitory Activity of Some Isonicotinic Acid Hydrazide Incorporated Novel Indazoles

https://doi.org/10.14233/ajchem.2023.27591
Rajasekhar Komarla Kumarachari
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati-517503, India
https://orcid.org/0000-0001-5611-1410
Mayandigari Guruvareddy
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati-517503, India
https://orcid.org/0000-0003-4560-3748
Aithepalli Thanuja
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati-517503, India
https://orcid.org/0000-0003-4444-3586
Agraharam Shresta
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati-517503, India
https://orcid.org/0009-0006-7324-2803
Gilla Shalini
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanur, Tirupati-517503, India
https://orcid.org/0009-0003-7894-7368
Kalikiri Sindhu
https://orcid.org/0009-0005-8758-3249
https://orcid.org/0009-0005-8758-3249
Jampana Bhargavi
https://orcid.org/0009-0003-9483-2798
https://orcid.org/0009-0003-9483-2798

Corresponding Author(s) : Rajasekhar Komarla Kumarachari

komarla.research@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Abstract

The present study reports the synthesis of isonicotinic acid hydrazide incorporated 7-(substituted benzylidine)-3-aryl-1-(pyridin-4-yl)-methanone)-2,3,4,5,6,7-hexahydro-1H-indazoles from substituted chalcones. The chalcones were synthesized by reacting cyclohexanone with a substituted aromatic aldehydes via the Claisen-Schmidt method. The IR, 1H NMR and mass spectral studies were used to characterize the synthesized compounds. In silico analysis was used to anticipate the biological activities of the synthezised compounds. PASS computer program predicted all title compounds to be anti-inflammatory in nature. All the synthesized compounds were screened for MMP-9 inhibitory activity by the gelatin zymography method. Among all the synthesized compounds B1, B3, B4 and B9 exhibited significant activity whereas rest of the synthesized compounds B2, B5, B6, B7 and B8 exhibited mild to moderate anti-inflammatory activity.

Keywords

Chalcones Indazoles Biological activity MMP-9 inhibitory activity
Kumarachari, R. K., Guruvareddy, M., Thanuja, A., Shresta, A., Shalini, G., Sindhu, K., & Bhargavi, J. (2023). Synthesis, in silico Biological Profile and MMP-9 Inhibitory Activity of Some Isonicotinic Acid Hydrazide Incorporated Novel Indazoles. Asian Journal of Chemistry, 35(5), 1264–1268. https://doi.org/10.14233/ajchem.2023.27591
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