Issue

Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

In vitro DNA Binding Interaction Studies of Hydrazones and Thiosemicarbazones Derived from Pyrazole Moiety

https://doi.org/10.14233/ajchem.2023.27619
Nichhapurada Shivakumara
Department of Chemistry, Ramaiah Institute of Technology, Bangalore-560054, India
https://orcid.org/0000-0002-0072-117X
P. Murali Krishna
Department of Chemistry, Ramaiah Institute of Technology, Bangalore-560054, India
https://orcid.org/0000-0002-0573-245X
N. Kallesha
Department of Phytochemistry, The Himalaya Drug Company, Makali, Bangalore-562123, India
https://orcid.org/0000-0002-3433-5875
Kereyagalahally H. Narasimhamurthy
Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysuru-570006, India
https://orcid.org/0000-0003-2349-0762

Corresponding Author(s) : Nichhapurada Shivakumara

shivakumarorganic@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 5 (2023): Vol 35 Issue 5, 2023

Abstract

In this work, the novel hydrazones and thiosemicarbazones derived from pyrazole moieties were synthesized by reacting 4-chloro-1-methyl-1H-pyrzolecarboxaldehyde with various hydrazides and thiosemicarbazides. All the synthesized compounds were characterized and confirmed with different spectroscopic techniques like FTIR, 1H NMR and LC-MS. The ct-DNA binding interaction studies were evaluated by using UV-visible spectroscopic and fluorescence spectrophotometric techniques with calf thymus DNA. The obtained binding constants of the synthesized were found to be 7 [8.44 × 104] > 4 [3.61 × 104] > 2 [3.60 × 104] > 1 [3.18 × 104] > 8 [2.85 × 104 M-1].

Keywords

Calf thymus DNA Hydrazones Thiosemicarbazones
Shivakumara, N., Krishna, P. M., Kallesha, N., & Narasimhamurthy, K. H. (2023). In vitro DNA Binding Interaction Studies of Hydrazones and Thiosemicarbazones Derived from Pyrazole Moiety. Asian Journal of Chemistry, 35(5), 1129–1134. https://doi.org/10.14233/ajchem.2023.27619
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. G. Verma, A. Marella, M. Shaquiquzzaman, M. Akhtar, M.R. Ali and M.M. Alam, J. Pharm. Bioallied Sci., 6, 69 (2014); https://doi.org/10.4103/0975-7406.129170
  2. J. de O.C. Brum, T.C.C. França, S.R. LaPlante and J.D. Figueroa-Villar, Mini-Rev. Med. Chem., 20, Issue 5 (2020); https://doi.org/10.2174/1389557519666191014142448
  3. M.A. Malik, O.A. Dar, P. Gull, M.Y. Wani and A.A. Hashmi, MedChemComm, 9, 409 (2018); https://doi.org/10.1039/C7MD00526A
  4. A. Antony and M. Angayarkani Sridevi, Asian J. Pharm. Clin. Res., 11, 66 (2018).
  5. M.X. Li, C.L. Chen, D. Zhang, J.Y. Niu and B.S. Ji, Eur. J. Med. Chem., 45, 3169 (2010); https://doi.org/10.1016/j.ejmech.2010.04.009
  6. M. Rudrapal, Int. Res. J. Pure Appl. Chem., 3, 232 (2013); https://doi.org/10.9734/IRJPAC/2013/3996
  7. S. Kumar, M.S. Niranjan, K.C. Chaluvaraju, C.M. Jamakhandi and K. Dayanand, J. Curr. Pharm. Res., 1, 39 (2010).
  8. H. Beraldo, Química Nova, 27, 461 (2004); https://doi.org/10.1590/S0100-40422004000300017
  9. E.J. Siddiqui, I. Azad, A.R. Khan and T. Khan, J. Drug Deliv. Therap., 9, 689 (2019); https://doi.org/10.22270/jddt.v9i3.2888
  10. F.R. Pavan, P.I.S. Maia, S.R.A. Leite, V.M. Deflon, A.A. Batista, D.N. Sato, S.G. Franzblau and C.Q.F. Leite, Eur. J. Med. Chem., 45, 1898 (2010); https://doi.org/10.1016/j.ejmech.2010.01.028
  11. M. Serda, D.S. Kalinowski, N. Rasko, E. Potucková, A. Mrozek-Wilczkiewicz, R. Musiol, J.G. Malecki, M. Sajewicz, A. Ratuszna, A. Muchowicz, J. Golab, T. Šimunek, D.R. Richardson and J. Polanski, PLoS One, 9, e110291 (2014); https://doi.org/10.1371/journal.pone.0110291
  12. B.C. Baguley, C.J. Drummond, Y.Y. Chen and G.J. Finlay, Molecules. 26, 552 (2021); https://doi.org/10.3390/molecules26030552
  13. M. Shakir, A. Abbasi, M. Azam and A.U. Khan, Spectrochim. Acta A Mol. Biomol. Spectrosc., 79, 1866 (2011); https://doi.org/10.1016/j.saa.2011.05.077
  14. N. Raman, K. Pothiraj and T. Baskaran, J. Mol. Struct., 1000, 135 (2011); https://doi.org/10.1016/j.molstruc.2011.06.006
  15. Q.-L. Zhang, J.-G. Liu, H. Chao, G.-Q. Xue and L.-N. Ji, J. Inorg. Biochem., 83, 49 (2001); https://doi.org/10.1016/S0162-0134(00)00132-X
  16. S. Ramakrishnan, D. Shakthipriya, E. Suresh, V.S. Periasamy, M.A. Akbarsha and M. Palaniandavar, Inorg. Chem., 50, 6458 (2011); https://doi.org/10.1021/ic1024185
  17. R. Manikandan, P. Viswanathamurthi, K. Velmurugan, R. Nandhakumar, T. Hashimoto and A. Endo, J. Photochem. Photobiol. B, 130, 205 (2014); https://doi.org/10.1016/j.jphotobiol.2013.11.008
  18. N. Vamsikrishna, M.P. Kumar, S. Tejaswi, A. Rambabu and Shivaraj, J. Fluoresc., 26, 1317 (2016); https://doi.org/10.1007/s10895-016-1818-z
  19. P. Murali Krishna, N.B. Gopal Reddy, B.G. Harish, Y.P. Patil and M. Nethaji, J. Mol. Struct., 1175, 97 (2019); https://doi.org/10.1016/j.molstruc.2018.07.053
  20. N.B. Gopal Reddy, P.M. Krishna, S.S. Shantha Kumar, Y.P. Patil and M. Nethaji, J. Mol. Struct., 1137, 543 (2017); https://doi.org/10.1016/j.molstruc.2017.02.009
  21. D.J. Patel, Acc. Chem. Res., 12, 118 (1979); https://doi.org/10.1021/ar50136a002
  22. Y.D. Chen, M.Y. Cai, Y. Zhang, W.L. Zheng and W.L. Ma, Pharm. Biotechnol., 12, 291 (2005).
  23. R. Eshkourfu, B. Cobeljic, M. Vujcic, I. Turel, A. Pevec, K. Sepcic, M. Zec, S. Radulovic, T. Srdic-Radic, D. Mitic, K. Andjelkovic and D. Sladic, J. Inorg. Biochem., 105, 1196 (2011); https://doi.org/10.1016/j.jinorgbio.2011.05.024
  24. X. Ling, W. Zhong, Q. Huang, K. Ni, J. Photochem. Photobiol. B, 93, 172 (2008); https://doi.org/10.1016/j.jphotobiol.2008.07.008
Read More
Author biographies is not available.
Download
AJC-35-5-12
Statistic
Read Counter : 0 Download : 0