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Vol. 35 No. 2 (2023): Vol 35 Issue 2, 2023

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Design, Synthesis of Some New Scaffolds based on Pyrrolyl-Pyridines as Potential Anticancer Agents

https://doi.org/10.14233/ajchem.2023.23974
Naga Mohan Mallisetty
Department of Chemistry, School of Science, GITAM University, Hyderabad-502102, India ; Symphony Pharma Pvt. Ltd., Biotech Park, Shameerpet, Medchal-Malkajgiri, Hyderabad-500101, India
Hanumantharao Ganipisetti
Department of Chemistry, National Taiwan University, No. 1, Section 4, Roosevelt Rd, Da'an, Taipei City, 10617, Taiwan
Debendra Majhi
Department of Chemistry, School of Science, GITAM University, Hyderabad-502102, India
Venkata Nagendra Kumar Putta
Department of Chemistry, School of Science, GITAM University, Hyderabad-502102, India

Corresponding Author(s) : Venkata Nagendra Kumar Putta

vputta@gitam.edu

Asian Journal of Chemistry, Vol. 35 No. 2 (2023): Vol 35 Issue 2, 2023

Abstract

Pyrrolyl-pyridine heterocyclic compounds have received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the synthesis of novel C–N, C–C bond formations like 5-substituted-1-benzyl-1H-pyrrolo[ 2,3-b]pyridines (3), 2-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenol (5) and screened for their anticancer activity. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, mass spectral techniques and elemental analysis. The outcomes of these compounds 2,6-difluorobenzyl-pyrrolidin-1H-pyrrolo[2,3-b]pyridine, 2,6-difluorobenzyl-N,N-dimethyl-1H-pyrrolo[2,3-b]-pyridin-5-amine had a signicant anticancer activity against human cervical cancer cell line (Hela) with IC50 4.8, 9.7 μg/mL and whereas pyrrolo[2,3-b]pyridin-5-phenol, pyrrolo[2,3-b]pyridin-5-vinylphenol are active against human breast cancer cell line (MCF-7) with IC50 8.1, 3.2 μg/mL, respectively.

Keywords

Azaindoles Anticancer activity C–C formation C-N formation Docking studies
Mohan Mallisetty, N., Ganipisetti, H., Majhi, D., & Nagendra Kumar Putta, V. (2023). Design, Synthesis of Some New Scaffolds based on Pyrrolyl-Pyridines as Potential Anticancer Agents. Asian Journal of Chemistry, 35(2), 468–474. https://doi.org/10.14233/ajchem.2023.23974
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