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Bioactive Phytoconstituents of Leucas zeylanica and its Molecular Docking Study
Corresponding Author(s) : Ranajit K. Sutradhar
Asian Journal of Chemistry,
Vol. 35 No. 2 (2023): Vol 35 Issue 2, 2023
Abstract
Bioactive phytoconstituents 1-3 were isolated from the chloroform extract of aerial parts of Leucas zeylanica. Structure of all the three compounds were elucidated by the spectroscopic analysis data. Three compounds showed good activities, but compound 2 exhibited significant in vitro antioxidant activity. In molecular docking study of compound 2 also showed good docking score within binding pocket of the selected proteins.
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- M.I. Molla and S.P. Ela, GSC Biol. Pharm. Sci., 16, 11 (2021); https://doi.org/10.30574/gscbps.2021.16.1.0184
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- B. Pradhan, D. Chakraborty and G.A. Subba, Phytochemistry, 29, 1693 (1990); https://doi.org/10.1016/0031-9422(90)80150-F
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References
M.I. Molla and S.P. Ela, GSC Biol. Pharm. Sci., 16, 11 (2021); https://doi.org/10.30574/gscbps.2021.16.1.0184
M. Napagoda, J. Gerstmeier, H. Butschek, S. Lorenz, D. Kanatiwela, M. Qader, A. Nagahawatte, S. De Soyza, G.B. Wijayaratne, A. Svatoš, L. Jayasingh, A. Koeberle and O. Werz, J. Ethnopharmacol., 224, 474 (2018); https://doi.org/10.1016/j.jep.2018.04.042
T.N. Misra, R.S. Singh, H.S. Pandey and S. Singh, Phytochemistry, 32, 1809 (1992); https://doi.org/10.1016/0031-9422(92)83152-O
T.N. Misra, R.S. Singh, H.S. Pandey and S. Singh, Indian J. Chem., 34B, 1108 (1995).
B. Pradhan, D. Chakraborty and G.A. Subba, Phytochemistry, 29, 1693 (1990); https://doi.org/10.1016/0031-9422(90)80150-F
R. Roshan, T. Kulkarini, S. Ketaki, G. Vedaati, D.S. Puranik and P.J. Swati, J. Nat. Prod., 76, 1836 (2013); https://doi.org/10.1021/np400002p
S.K. Sadhu, E. Okuyama, H. Fujimoto and M. Ishibashi, J. Nat. Prod., 69, 988 (2006); https://doi.org/10.1021/np058118m
I. Fatima, I. Ahmad, I. Anis, A. Malik, N. Afza, I. Iqbal, M. Latif, Arch. Pharm. Res., 31, 999 (2008); https://doi.org/10.1007/s12272-001-1259-5
N. Nidhal, X. Ming, G. Chen, B. Zhang, C. Han and X. Song, Biochem. Syst. Ecol., 89, 104006 (2020); https://doi.org/10.1016/j.bse.2020.104006
S.B. Kedare and R.P. Singh, J. Food Sci. Technol., 48, 412 (2011); https://doi.org/10.1007/s13197-011-0251-1
M.J. Frisch, G.W. Trucks, H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, G. Scalmani, V. Barone, G.A. Petersson, H. Nakatsuji, X. Li, M. Caricato, A. Marenich, J. Bloino, B.G. Janesko, R. Gomperts, B. Mennucci, H.P. Hratchian, J.V. Ortiz, A.F. Izmaylov, J.L. Sonnenberg, D. Williams-Young, F. Ding, F. Lipparini, F. Egidi, J. Goings, B. Peng, A. Petrone, T. Henderson, D. Ranasinghe, V.G. Zakrzewski, J. Gao, N. Rega, G. Zheng, W. Liang, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Hada, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, T. Vreven, K. Throssell, J.A. Montgomery, Jr., J.E. Peralta, F. Ogliaro, M. Bearpark, J.J. Heyd, E. Brothers, K.N. Kudin, V.N. Staroverov, R. Kobayashi, T. Keith, J. Normand, K. Raghavachari, A. Rendell, J.C. Burant, S.S. Iyengar, J. Tomasi, M. Cossi, J.M. Millam, M. Klene, C. Adamo, R. Cammi, J.W. Ochterski, R.L. Martin, K. Morokuma, O. Farkas, J.B. Foresman and D.J. Fox, Gaussian Inc., Wallingford CT (2016).
S. Dallakyan and A.J. Olson, Eds.: In: J.E. Hempel, C.H. Williams and C.C. Hong, Small-Molecule Library Screening by Docking with PyRx, In: Chemical Biology Methods Protocol, Springer: New York, pp. 243-250 (2015).
W.L. Delano, The PyMOL Molecular Graphics System, De-Lano Scientific, San Carlos, USA (2002).
Accelrys Discovery Studio Version 4.1, Accelrys, San Diego, USA (2017).
R. Bhoria and S. Kainsa, Int. J. Pharm., 3, 77 (2013).