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Vol. 35 No. 1 (2023): Vol 35 Issue 1

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Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3] Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence

https://doi.org/10.14233/ajchem.2023.26932
Venkateswarlu Chimaladenne
Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India ; Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India
Sri Rama Krishna Surapureddi
Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India
Krishna Reddy Valluru
Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India
Anil Kampli
Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India
Pradeep Kumar Brahman
Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India
Veera Babu Gudise
Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India
Somarapu Vijaya Laxmi
Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India; Department of Chemistry, Palamuru University, Mahabubnagar-509001, India

Corresponding Author(s) : Somarapu Vijaya Laxmi

vijaya1214@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 1 (2023): Vol 35 Issue 1

Abstract

A microwave assisted protocol for the development of fully substituted dihydrofurans has been explained as a three component triple cascade reaction between pyridinium ylide, phenacyl nitriles and aldehydes. This [1+1+3] annulation protocol produced the dihydrofurans having two stereocentres. A total of 14 molecules have been synthesized with high chemical yields.

Keywords

Microwave irradiation Three-component reaction Pyridinium salts Triple cascade [1 1 3] Annulation 4,5-Dihydrofuran
Chimaladenne, V., Rama Krishna Surapureddi, S., Reddy Valluru, K., Kampli, A., Kumar Brahman, P., Babu Gudise, V., & Vijaya Laxmi, S. (2022). Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3] Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence. Asian Journal of Chemistry, 35(1), 224–232. https://doi.org/10.14233/ajchem.2023.26932
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