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Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Copyright (c) 2023 Neelam Yadav, Ravi Kumar, Sarita Sangwan, Sonu Chauhan, Vidhi Dhanda, Reena Rani, Sheetu Devi, Anil Duhan

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Ultrasonic Assisted Three Component Synthesis of 3-Cyano-pyridine-2(1H)-ones

https://doi.org/10.14233/ajchem.2023.30778
Neelam Yadav
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0000-0003-1159-0969
Ravi Kumar
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India MAP Section, Department of Genetics and Plant Breeding, Charan Singh Haryana Agricultural University, Hisar-125004, India Center for Bio-Nanotechnology, Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0000-0001-8146-9799
Sarita Sangwan
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0000-0001-8413-1478
Sonu Chauhan
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0000-0001-7374-2337
Vidhi Dhanda
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0009-0006-4854-1772
Reena Rani
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0009-0003-3325-121X
Sheetu Devi
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0009-0003-7691-5450
Anil Duhan
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar-125004, India
https://orcid.org/0000-0001-8087-3677

Corresponding Author(s) : Neelam Yadav

raon5577@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Abstract

The requirements of sustainability and the green chemistry principles have prompted organic chemistry researchers to come up with novel methods for the synthesis of organic compounds that require minimum energy consumption and pose lesser environment harm. Ultrasonication of reaction mixtures is one such methodology. High frequency sound waves are known to emit energy that is utilized in product generation. Attempts were made to synthesize 2-pyridone derivatives using ultrasonication assisted method of synthesizing 3-cyano-pyridine-2(1H)-one starting from a three component one pot reaction. The reaction between cyanoacetamide, aromatic ketones and substituted aromatic aldehydes in the presence of NaOH as base yielded 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitrile derivatives as a result of one-pot multicomponent reaction. The synthesized 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitrile derivatives were characterized by 1H NMR, 13C NMR, HRMS and FTIR spectra. Ultrasonication has been found to significantly reduce reaction time, enhance reaction rate and yield compared to conventional heating methods.

Keywords

Ultrasonication Heterocycles 3-Cyano-pyridine-2(1H)-ones Multicomponent reaction
Yadav, N., Kumar, R., Sangwan, S., Chauhan, S., Dhanda, V., Rani, R., … Duhan, A. (2023). Ultrasonic Assisted Three Component Synthesis of 3-Cyano-pyridine-2(1H)-ones. Asian Journal of Chemistry, 35(12), 3118–3126. https://doi.org/10.14233/ajchem.2023.30778
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