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Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Copyright (c) 2023 Rahul Goel, Meenu Mangal, Aruna Sharma, Pradeep Kumar, Alka Gupta

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Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery Efficiency

https://doi.org/10.14233/ajchem.2023.30738
R. Goel
Department of Chemistry, JECRC University, Ramchandpura, Sitapura Extension, Jaipur-303905, India
https://orcid.org/0000-0002-4388-602X
M. Mangal
Department of Chemistry, Poddar International College, Tagore Lane, Shipra Path, Mansarovar, Jaipur-302020, India
https://orcid.org/0000-0001-5564-7838
A. Sharma
Department of Chemistry, JECRC University, Ramchandpura, Sitapura Extension, Jaipur-303905, India
https://orcid.org/0000-0002-5168-9579
P. Kumar
CSIR-Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi-110007, India
https://orcid.org/0000-0001-5874-8191
A. Gupta
Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi-110003, India
https://orcid.org/0000-0003-2042-9886

Corresponding Author(s) : R. Goel

goel.rahul07@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Abstract

In this study, a set of short sequences of amphiphilic peptides composed of synthetic amino acids β-alanine and ornithine were designed. The synthesis of these peptides was carried out in a solution phase and then self-assembled into cationic nanostructures. The formation of cationic nanostructures was confirmed using dynamic light scattering (DLS) and the morphology of the nanostructures was studied using transmission electron microscopy (TEM), which revealed that the nanostructure adopted a spherical shape. To gain insight into the conformation of both solid samples and peptide solutions, the Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopic analysis were performed. Furthermore, the ability of these nanostructures to encapsulate hydrophobic drugs were also investigated. Three different drugs were tested as model drugs: L-dopa, an anti-Parkinson’s drug; curcumin, anti-cancerous drug and tetrabenazine, anti-Huntington’s drug. The nanostructures exhibited the capacity to encapsulate these drugs in varying ratios.

Keywords

β-Peptide Amphiphilic foldamers Self-assembly Cationic nanostructures Drug delivery systems
Goel, R., Mangal, M., Sharma, A., Kumar, P., & Gupta, A. (2023). Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery Efficiency. Asian Journal of Chemistry, 35(12), 3093–3104. https://doi.org/10.14233/ajchem.2023.30738
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