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Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Copyright (c) 2023 Kotaiah Kandula, Nagaraju Myakala, Nagamani Rayala, Satheesh Kuna, Sumathi Vodnala, Vishnu Thumma, A.K.D. Bhavani

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Novel Series of 1,2,3-Triazoles Tethered to Pyrazolo[3,4-d]pyrimidine Scaffold with Methoxyphenoxy Linker

https://doi.org/10.14233/ajchem.2023.29040
Kotaiah Kandula
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-4601-8463
Nagaraju Myakala
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-2479-8921
Nagamani Rayala
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-8148-0530
Satheesh Kuna
Department of Chemistry, Geethanjali College of Engineering and Technology, Cheeryal, Keesara, Medchal-501301, India
https://orcid.org/0000-0001-5979-9740
Sumathi Vodnala
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0001-9997-3686
Vishnu Thumma
Department of Sciences and Humanities, Matrusri Engineering College, Saidabad, Hyderabad-500059, India
https://orcid.org/0000-0001-6830-3671
A.K.D. Bhavani
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-5493-0663

Corresponding Author(s) : A.K.D. Bhavani

durgabhavani237@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Abstract

A novel series of hybrid heterocycles having pyrazolopyrimidine based 1,2,3-triazole scaffold with two ether linkages were synthesized by 1,3-dipolar cycloaddition reaction of pyrazolopyrimidines tethered to phenoxy alkynes and differently substituted aromatic azides using CuSO4·5H2O and sodium ascorbate mixture as catalyst in DMSO-H2O solvent mixture. The synthesized triazole hybrids were characterized by using various spectroscopic techniques.

Keywords

Pyrazolopyrimidines tethered to phenoxy alkynes Hybrid triazoles Click reaction Dihydroxy acetophenone
Kandula, K., Myakala, N., Rayala, N., Kuna, S., Vodnala, S., Thumma, V., & Bhavani, A. (2023). Synthesis of Novel Series of 1,2,3-Triazoles Tethered to Pyrazolo[3,4-d]pyrimidine Scaffold with Methoxyphenoxy Linker. Asian Journal of Chemistry, 35(12), 3087–3092. https://doi.org/10.14233/ajchem.2023.29040
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