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Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Copyright (c) 2023 Prof. Dilip Kumar Kakati

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Synthesis and Characterization of Peppermint Oil Loaded Complex Coacervates of Chitosan Phosphate/κ-Carrageenan and Evaluation of their Antibacterial Activity

https://doi.org/10.14233/ajchem.2023.30578
A. Sarma
Department of Chemistry, Gauhati University, Guwahati-781014, India
https://orcid.org/0009-0006-7822-1681
J. Rabha
Department of Botany, Gauhati University, Guwahati-781014, India
https://orcid.org/0000-0003-4955-877X
M. Upadhyaya
Department of Chemistry, Chayduar College, Gohpur-784168, India
https://orcid.org/0000-0002-6344-1714
D.K. Kakati
Department of Chemistry, Chayduar College, Gohpur-784168, India
https://orcid.org/0009-0004-5735-5491

Corresponding Author(s) : D.K. Kakati

dkk.chem@gauhati.ac.in

Asian Journal of Chemistry, Vol. 35 No. 12 (2023): Vol 35 Issue 12, 2023

Abstract

Peppermint oil has been in use as traditional medicine for several common ailments besides being used as flavourings in foods and beverages. Like other essential oils it is also susceptible to oxidative degradation on exposure to oxygen, light and heat, which results  in its decreased shelf life. Complex coacervation is a commonly used technique to encapsulate essential oils to give protection against  degradation as well as providing a carrier vehicle for sustained release. In present work, the peppermint oil was encapsulated in a  complex coacervate from a chitosan derivative, chitosan phosphate and κ-carrageenan in the presence of glutaraldehyde as  crosslinking agent. The reaction conditions were optimized .The highest yield of the coacervate was recorded at pH 4.6 of the reaction  medium and at a ratio of 2:4 by volume of 0.3% (w/v) solution of chitosan phospahate and κ-carrageenan. The effect of the variation of  amount of crosslinker on the morphology and swelling property of the coacervate was also investigated and both the properties were  found to be affected. A maximum loading efficiency of 84.19% was observed. The swelling and release studies revealed that both were  pH dependent and release of peppermint oil from the coacervate showed a sustained release profile over a period of 72 h. The  peppermint oil loaded coacervates were investigated for their antibacterial activities against Micrococcus luteus, Staphylococcus  epidermidis, Escherichia coli, Klebsiella pneumonia and Proteus vulgarus and found to be mildly effective against all of them. 

Keywords

Peppermint oil Chitosan phosphate κ-Carrageenan Micrococcus luteus Staphylococcus epidermidis Escherichia coli Klebsiella pneumonia Proteus vulgarus
Sarma, A., Rabha, J., Upadhyaya, M., & Kakati, D. (2023). Synthesis and Characterization of Peppermint Oil Loaded Complex Coacervates of Chitosan Phosphate/κ-Carrageenan and Evaluation of their Antibacterial Activity. Asian Journal of Chemistry, 35(12), 3013–3021. https://doi.org/10.14233/ajchem.2023.30578
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References
  1. M. Tafrihi, M. Imran, T. Tufail, T.A. Gondal, G. Caruso, S. Sharma, R. Sharma, M. Atanassova, L. Atanassov, P.V.T. Fokou and R. Pezzani, Molecules, 26, 1118 (2021); https://doi.org/10.3390/molecules26041118
  2. M. Moghaddam, M. Pourbaige, H.K. Tabar, N. Farhadi and S.M.A. Hosseini, J. Essen. Oil Bearing Plants, 16, 506 (2013); https://doi.org/10.1080/0972060X.2013.813265
  3. N. Alammar, L. Wang, B. Saberi, J. Nanavati, G. Holtmann, R.T. Shinohara and G.E. Mullin, BMC Complement. Altern. Med., 19, 21 (2019); https://doi.org/10.1186/s12906-018-2409-0
  4. M.S. Alam, P.K. Roy, R. Miah, S.H. Mollick, M.R. Khan, C. Mahmud and S. Khatun, Mymensingh Med. J., 22, 27 (2013).
  5. N.E. Ertürk and S. Tasci, Complement. Ther. Med., 56, 102587 (2021); https://doi.org/10.1016/j.ctim.2020.102587
  6. X. Liu, F. Xue and B. Adhikari, Sustain. Food Technol., 1, 426 (2023); https://doi.org/10.1039/D3FB00004D
  7. Z.J. Dong, A. Toure, C.S. Jia, X.M. Zhang and S.Y. Xu, J. Microencapsul., 24, 634 (2007); https://doi.org/10.1080/02652040701500632
  8. J. Yang and O.N. Ciftci, Food Res. Int., 87, 83 (2016); https://doi.org/10.1016/j.foodres.2016.06.022
  9. Z. Dong, Y. Ma, K. Hayat, C. Jia, S. Xia and X. Zhang, J. Food Eng., 104, 455 (2011); https://doi.org/10.1016/j.jfoodeng.2011.01.011
  10. N. Kasiri and M. Fathi, Cellulose, 25, 319 (2018); https://doi.org/10.1007/s10570-017-1574-5
  11. C. Deka, D. Deka, M.M. Bora, D.K. Jha and D.K. Kakati, J. Drug Deliv. Sci. Technol., 35, 314 (2016); https://doi.org/10.1016/j.jddst.2016.08.007
  12. S. Ghayempour and M. Montazer, Carbohydr. Polym., 205, 589 (2018); https://doi.org/10.1016/j.carbpol.2018.10.078
  13. C. Liu, M. Li, N. Ji, J. Liu, L. Xiong and Q. Sun, J. Agric. Food Chem., 65, 8363 (2017); https://doi.org/10.1021/acs.jafc.7b02938
  14. A. Shetta, J. Kegere and W. Mamdouh, Int. J. Biol. Macromol., 126, 731 (2019); https://doi.org/10.1016/j.ijbiomac.2018.12.161
  15. H. Parkzad, I. Alemzadeh and A. Kazemi, J. Int. Eng. Trans. B Appl., 26, 807 (2013).
  16. G. Huang, Y. Liu and L. Chen, Drug Deliv., 24, 108 (2017); https://doi.org/10.1080/10717544.2017.1399305
  17. C. Deka, L. Aidew, N. Devi, A.K. Buragohain and D.K. Kakati, J. Biosci., 27, 1659 (2016); https://doi.org/10.1080/09205063.2016.1226051
  18. B.K. Sridhar, A. Srinatha and M.S. Khan, Indian J. Pharm. Sci., 72, 18 (2010); https://doi.org/10.4103/0250-474X.62230
  19. R.K. Das, N. Kasoju and U. Bora, Nanomedicine, 6, 153 (2010); https://doi.org/10.1016/j.nano.2009.05.009
  20. J. Hudzicki, Kirby-Bauer Disk Diffusion Susceptibility Test Protocol, American Society for Microbiology (2016).
  21. S. Phongpaichit, J. Nikom, N. Rungjindamai, J. Sakayaroj, N. Hutadilok- Towatana, V. Rukachaisirikul and K. Kirtikara, FEMS Immunol. Med. Microbiol., 51, 517 (2007); https://doi.org/10.1111/j.1574-695X.2007.00331.x
  22. M. Fernandes Queiroz, K. Melo, D. Sabry, G. Sassaki and H. Rocha, Mar. Drugs, 13, 141 (2015); https://doi.org/10.3390/md13010141
  23. W.A.K. Mahmood, M.M.R. Khan and T.C. Yee, J. Phys. Sci., 25, 123 (2014).
  24. N. Pramanik, D. Mishra, I. Banerjee, T.K. Maiti, P. Bhargava and P. Pramanik, Int. J. Biomater., 2009, 1 (2009); https://doi.org/10.1155/2009/512417
  25. M. Yilmaztekin, S. Levic, A. Kaluševic, M. Cam, B. Bugarski, V. Rakic, V. Pavlovic and V. Nedovic, J. Microencapsul., 36, 109 (2019); https://doi.org/10.1080/02652048.2019.1607596
  26. M.E.I. Badawy, N.E.M. Taktak, O.M. Awad, S.A. Elfiki and N.E.A. El-Ela, J. Macromol. Sci. B Phys., 56, 359 (2017); https://doi.org/10.1080/00222348.2017.1316640
  27. R.M. Silverstein, G.C. Bassler and T.C. Morrill, Spectroscopic Identification of Organic Compounds, edn. 5, John Wily & Sons: New York (1981).
  28. S. Kumar and J. Koh, Int. J. Mol. Sci., 13, 6102 (2012); https://doi.org/10.3390/ijms13056102
  29. N. Al-Zebari, S.M. Best and R.E. Cameron, J. Phys. Mater., 2, 015003 (2019); https://doi.org/10.1088/2515-7639/aae9ab
  30. T.N. Carneiro, D.S. Novaes, R.B. Rabelo, B. Celebi, P. Chevallier, D. Mantovani, M.M. Beppu and R.S. Vieira, Macromol. Biosci., 13, 1072 (2013); https://doi.org/10.1002/mabi.201200482
  31. S. Distantina, R. Rochmadi, M. Fahrurrozi and W. Wiratni, Eng. J., 17, 57 (2013); https://doi.org/10.4186/ej.2013.17.3.57
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