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Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Copyright (c) 2023 Dr Qasim Ullah, NAHID FATEMA, VIJULITHA MANGA, ARIFUDDIN MOHAMMAD, SALMAN AHMAD KHAN, MOHAMMAD ARIF PATHAN

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Green and Efficient Chemo-selective Synthesis of Chalcone Imines (α,β-Unsaturated imine) using Baker’s Yeast

https://doi.org/10.14233/ajchem.2023.30302
Qasim Ullah
Chemistry Section, School of Sciences, Maulana Azad National Urdu University, Gachibowli, Hyderabad-500032, India
https://orcid.org/0000-0002-6133-7083
NAHID FATEMA
Chemistry Section, School of Sciences, Maulana Azad National Urdu University, Gachibowli, Hyderabad-500032, India
M. VIJJULATHA
OSMANIA UNIVERSITY HYDERABAD
Pathan Mohammad Arif
Department of Chemistry, Maulana Azad College of Arts, Science & Commerce, Aurangabad-431001, India
SALMAN AHMED KHAN
Chemistry Section, School of Sciences, Maulana Azad National Urdu University, Gachibowli, Hyderabad-500032, India
MOHAMMED ARIFUDDIN
Directorate of Distance Education, Maulana Azad National Urdu University, Gachibowli, Hyderabad-500032, India
https://orcid.org/0000-0002-0158-5683
Syed Kashif Ali
Department of Chemistry, Faculty of Science, Jazan University, Jazan P.O. Box 82817, Saudi Arabia
https://orcid.org/0000-0002-3323-6672
REHAB EBAID AZOOZ
Department of Chemistry, Faculty of Science, Jazan University, Jazan P.O. Box 82817, Saudi Arabia
https://orcid.org/0000-0002-5963-7300

Corresponding Author(s) : Qasim Ullah

drqasimullah@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Abstract

A simple, efficient, chemo-selective and sustainable biocatalytic method for the synthesis of a,b-unsaturated imines or chalcone- mines (3a-l) was developed by using Baker’s yeast. When, chalcones (1a-b) were reacted with the substituted anilines (2a-f) in the presence of Baker’s yeast act as a whole cell biocatalyst at ambient temperature in ethanol as a green solvent to afford the a,b-unsaturated imines or chalcone-imines (3a-l) in good to excellent yield. The reaction procedure was easy to follow and takes place at room temperature (25-28 ºC). The commercially available Baker’s yeast is very cheap and affordable catalyst, easy to use and facilitate this method as an effective and facile chemo-selective synthesis of a,b-unsaturated imines (chalcone-imines) (3a-l). This is the first report about the biocatalytic reactions of a,b-unsaturated imines (chalcone-imines) (3a-l) formation and it is assumed that this method will open an gateway for the organic chemists to design and synthesized chemo-selective chalcone imines.

Keywords

α,β‐Unsaturated imines Chalcone-imines Biocatalysis Baker’s yeast Chemo-selective
Ullah, Q., FATEMA, N., VIJJULATHA, M., Arif, P. M., KHAN, S. . A., ARIFUDDIN, M., … AZOOZ, R. E. (2023). Green and Efficient Chemo-selective Synthesis of Chalcone Imines (α,β-Unsaturated imine) using Baker’s Yeast. Asian Journal of Chemistry, 35(11), 2809–2814. https://doi.org/10.14233/ajchem.2023.30302
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