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Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Copyright (c) 2023 Usha Rani Peddaboina, ANITHA SADHULA, Ravinder Nath Anisetti

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Coumarin Imidazolone Hybrid as Inhibitor of Topoisomerase Type II and Hsp90 and as Potent Antimicrobials

https://doi.org/10.14233/ajchem.2023.28004
Usha Rani Peddaboina
Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0003-0089-5935
ANITHA SADHULA
Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0003-3672-8266
Ravinder Nath Anisetti
Department of Botany, Central University of Kashmir, Green Campus, Duderhama, Ganderbal-191201, India
https://orcid.org/0000-0002-2682-1056

Corresponding Author(s) : Ravinder Nath Anisetti

ravindernathaniseti@yahoo.com

Asian Journal of Chemistry, Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Abstract

In present study, coumarin imidazolone hybrids were synthesized on the basis of the molecular docking analysis of the compounds (11a-h) by using PyRx 0.8 software. The molecules docking studies were performed against the targets Hsp90 and human type IIA DNA topoisomerase and compared the same with standard drugs fluconazole and doxorubicin. Among all the compounds 11d (-12.7 kcal/mol) and 11f (-12.4 kcal/mol) showed good binding affinity towards human Hsp90 and 11d (-11.5 kcal/mol) and 11e (-11.4 kcal/mol) showed good binding affinity against human type IIA DNA topoisomerase. Based on the positive results a series of eight novel titled compounds (1-(4-(4-(arylidene)-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)-2-oxo-2H-chromene-3- arbohydrazides (11a-h) have been prepared by the method of condensation of 1-(4-acetylphenyl)-4-arylidene-2-phenyl-1H-imidazol- (4H)-ones (5a-h) with 2-oxo-2H-chromene-3-carbohydrazide (10). Characterization of the synthesized compounds were conducted by FT-IR, 1H NMR, 13C NMR, mass spectral studies and screened for their antioxidant, anticancer and antimicrobial activities. The compounds were analyzed for physico-chemical and pharmacokinetic properties of all the compounds showed good to moderate properties.

Keywords

Imidazolones Coumarins Human Hsp90 Human Type IIA DNA topoisomerases Anticancer activity
Peddaboina, U. R., SADHULA, A., & Anisetti, R. N. (2023). Coumarin Imidazolone Hybrid as Inhibitor of Topoisomerase Type II and Hsp90 and as Potent Antimicrobials. Asian Journal of Chemistry, 35(11), 2689–2702. https://doi.org/10.14233/ajchem.2023.28004
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