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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 PRAVEEN KUMAR MUPPARAPU, Dr. NAMRATHA VADDIRAJU, MOHAN KURRA

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Synthesis and in vitro Antimicrobial Screening of Benzofuran-3(2H)-one Linked Geminal bis 1,2,3-Triazole Hybrid Derivatives

https://doi.org/10.14233/ajchem.2023.28036
PRAVEEN KUMAR MUPPARAPU
Department of Chemistry, Satavahana University, Karimnagar-505002, India
NAMRATHA VADDIRAJU
Department of Chemistry, Satavahana University, Karimnagar-505002, India
https://orcid.org/0000-0003-2569-5091
MOHAN KURRA
Department of Pharmaceutical Chemistry, Telangana University, Nizamabad-503322, India
https://orcid.org/0000-0002-4339-1190

Corresponding Author(s) : NAMRATHA VADDIRAJU

namrathav69@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

A series of novel hybrid derivatives, 2,2-di(1H-1,2,3-triazol-1-yl)benzofuran-3(2H)-ones, were synthesized from o-hydroxyacetophenones via a two-step process involving sodium azide, iodine and sodium bicarbonate, followed by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in aqueous conditions. These compounds were characterized using 1H NMR, 13C NMR and mass spectra and analyzed in vitro against bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger). Compounds 3f, 3h and 3n showed notable antibacterial activity (MIC = 50 μg/mL), comparable to streptomycin, while compounds 3b, 3f and 3h exhibited similar antifungal activity (MIC = 50 μg/mL), comparable to standard clotrimazole. Compound 3f displayed superior antimicrobial efficacy among the tested compounds.

Keywords

Benzofuranone 3-Coumaranone bis-Triazole Sodium azide gem-Diazides
MUPPARAPU, P. K., VADDIRAJU, N., & KURRA, M. (2023). Synthesis and in vitro Antimicrobial Screening of Benzofuran-3(2H)-one Linked Geminal bis 1,2,3-Triazole Hybrid Derivatives. Asian Journal of Chemistry, 35(10), 2543–2548. https://doi.org/10.14233/ajchem.2023.28036
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