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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 K. SUNITHA, SMITHA NAIR, P. PALANISAMY

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In vitro Antidiabetic and Anticancer Activity of Some Novel Diazenyl Benzene Sulphonamide Derivatives

https://doi.org/10.14233/ajchem.2023.28257
K. SUNITHA
Department of Chemistry and Research Centre, Pioneer Kumaraswamy College (Affiliated to Manonmaniam Sundaranar University, Tirunelveli), Nagercoil-629003, India
https://orcid.org/0000-0002-2886-5036
SMITHA NAIR
Department of Chemistry, Sree Ayyappa College for Women, Chunkankadai-629807, India
https://orcid.org/0000-0002-1640-9404
P. PALANISAMY
Department of Chemistry and Research Centre, Pioneer Kumaraswamy College (Affiliated to Manonmaniam Sundaranar University, Tirunelveli), Nagercoil-629003, India
https://orcid.org/0000-0002-6679-1381

Corresponding Author(s) : SMITHA NAIR

smithanair@sreeayyappacollege.com

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

A series of novel 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 were
synthesized and FT-IR, 1H NMR, 13C NMR and GC-MS spectral data were used to investigate the structures of the synthesized sulphonamide derivatives. The antioxidant activity of 2-[(5-phenyl-1,3,4-thiadiazole-2-imino)substituted benzene]diazenyl benzene sulphonamide derivatives (VII)6-10 was done using DPPH technique. Compounds (VII)7 and (VII)9 displayed excellent antioxidant activity when compared to standard ascorbic acid. The in vitro antidiabetic activity on α-amylase and α-glucosidase studies indicated compound (VII)7 as promising inhibitor of α-amylase and α-glucosidase. The cytotoxic activity of the synthesized compound (VII)9 was tested against human colon (HCT-116), lung (A549), breast (MCF-7) cancer cell lines and fibroblast (L929) normal mouse lines. The results showed that compound (VII)9 has good cytotoxic activity. 

Keywords

Sulphonamide Derivatives Antidiabetic activity α-Glucosidase activity Antioxidant activity Cytotoxic activity
SUNITHA, K., NAIR, S., & PALANISAMY, P. (2023). In vitro Antidiabetic and Anticancer Activity of Some Novel Diazenyl Benzene Sulphonamide Derivatives. Asian Journal of Chemistry, 35(10), 2407–2412. https://doi.org/10.14233/ajchem.2023.28257
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