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Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Copyright (c) 2023 M. JEEVITHA, SHUBASHINI K. SRIPATHI

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This work is licensed under a Creative Commons Attribution 4.0 International License.

GC-MS Profiling and Anti-quorum Sensing Screening of Leaf and Bark Extracts and Fractions of Acacia ferruginea: A Threatened Medicinal Plant

https://doi.org/10.14233/ajchem.2023.24027
M. JEEVITHA
Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641043, India
https://orcid.org/0000-0002-4523-3081
SHUBASHINI K. SRIPATHI
Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641043, India
https://orcid.org/0000-0003-1386-0280

Corresponding Author(s) : M. JEEVITHA

jeevichemistry@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 10 (2023): Vol 35 Issue 10, 2023

Abstract

The present study was carried out to screen the anti-quorum sensing property of the possible bioactive fractions and valuable secondary metabolites from the hexane extract of bark and leaves of Acacia ferruginea. Solvent extraction of the plant material using hexane followed by preparative thin layer separation and centrifugal thin layer separation of the extract using silica gel yields 12 and 5 fractions, respectively. Spectral characterization (UV, FT-IR) and anti-QS screening were done for the fractions. GC-MS was done for both nonpolar extracts and cyclograph fractions. The active moieties from bark and leaves fractions were established on the basis of UV, FT-IR and GC-MS. From the anti-QS screening studies, the active fractions were determined. A total of 17 fractions were obtained from the hexane extract of bark and leaves of Acacia ferruginea. Among these fractions, 5 fractions were shown to exhibit activity against Chromobacterium violaceum, while 2 fractions showed moderate activity.

Keywords

Anti-quorum sensing Biofilm GC-MS Acacia ferruginea Chromobacterium violaceum Traditional medicinal plants
JEEVITHA, M., & SRIPATHI, S. K. (2023). GC-MS Profiling and Anti-quorum Sensing Screening of Leaf and Bark Extracts and Fractions of Acacia ferruginea: A Threatened Medicinal Plant. Asian Journal of Chemistry, 35(10), 2399–2406. https://doi.org/10.14233/ajchem.2023.24027
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