Copyright (c) 2026 ThanhDuc Hoang, nguyen Thi Thu Trang, Nguyen Anh Tuan
This work is licensed under a Creative Commons Attribution 4.0 International License.
Structural Characterisation and Kinetic Evaluation of Quinine Sulphate Release from Polylactic Acid/Chitosan Drug Carrier Systems
Corresponding Author(s) : Hoang Thanh Duc
Asian Journal of Chemistry,
Vol. 38 No. 6 (2026): Vol. 38 Issue No 6, 2026
Abstract
This study fabricated polylactic acid/chitosan (PLA/CS) drug delivery materials containing quinine sulphate (QS) to control the release rate of quinine sulphate. FTIR, SEM, and DSC analyses revealed a two-phase heterostructure consisting of a PLA matrix and a dispersed phase composed of micrometre-sized chitosan particles associated with QS. The components in the material are linked together via hydrogen bonding interactions between hydroxyl groups. Drug release assays showed that the QS content directly affects the kinetics, with samples containing 10-20% QS exhibiting the highest release rate. Notably, the release rate at pH 7.4 was higher than that at pH 2.0, which is favourable for targeted release in the small intestine. The release behaviour followed the Korsmeyer-Peppas kinetic model and was governed primarily by a Fickian diffusion mechanism. These findings suggest that the PLA/CS/QS material system has considerable potential for dose optimisation and improved therapeutic performance in biomedical applications.
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- M.P. Motloung and M.J. Mochane, Express Polym. Lett., 19, 1092 (2025); https://doi.org/10.3144/expresspolymlett.2025.82
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References
M.P. Motloung and M.J. Mochane, Express Polym. Lett., 19, 1092 (2025); https://doi.org/10.3144/expresspolymlett.2025.82
V.S. Silverajah, A.I. Nor, Z. Norhazlin, M. Wan, Y. Wan and A.H. Hazimah, Molecules, 17, 11729 (2012); https://doi.org/10.3390/molecules171011729
H. Goshtasbi, S. Awale, M. S. Amini-Fazl, M. Fathi, A. Movafeghi, J. Barar and Y. Omidi, Int. J. Biol. Macromol., 279, 135280 (2024); https://doi.org/10.1016/j.ijbiomac.2024.135280
S.K. Naskar and S.K. Kundu, J. Drug Deliv. Sci. Technol., 53, 101204 (2019); https://doi.org/10.1016/j.jddst.2019.101204
M. Prabaharan, M.A. Rodriguez-Perez, J.A. DeSaja and J.F. Mano, J. Biomed. Mater. Res. B Appl. Biomater., 81, 427 (2007); https://doi.org/10.1002/jbm.b.30680
X. Huang and C.S. Brazel, J. Control. Release, 73, 121 (2001); https://doi.org/10.1016/S0168-3659(01)00248-6
A. Gupta, P. Patel, S. Shah, R. Verma and K. Iyer, Future J. Pharm. Sci., 11, 37 (2025); https://doi.org/10.1186/s43094-025-00789-4
N.J. White, Clin. Pharmacokinet., 30, 263 (1996); https://doi.org/10.2165/00003088-199630040-00002
A.H. Romero, K.N. Gonzalez and M.A. Sabino, Front. Chem., 13, 1622566 (2025); https://doi.org/10.3389/fchem.2025.1622566
L.R. Michels, L. Bajerski, T.R. Maciel, L.M. Colomé and S.E. Haas, J. Appl. Pharm. Sci., 6, 9 (2016); https://doi.org/10.7324/JAPS.2016.60202
A. Dev, N.S. Binulal, A. Anitha, S.V. Nair, T. Fruike, H. Tamura and R. Jayakumar, Carbohydr. Polym., 80, 833 (2010); https://doi.org/10.1016/j.carbpol.2009.12.040
R. Nanda, A. Sasmal and P.L. Nayak, Carbohydr. Polym., 83, 988 (2011); https://doi.org/10.1016/j.carbpol.2010.09.009
H. Abbasi, M. Kouchak, Z. Mirveis, F. Hajipour, M. Khodarahmi, N. Rahbar and S. Handali, Adv. Pharm. Bull., 13, 7 (2022); https://doi.org/10.34172/apb.2023.009
T.N.T. Nguyen and T.N.H. Nguyen, Dong Thap Univ. J. Sci., 14, 88 (2025); https://doi.org/10.52714/dthu.14.5.2025.1530
