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Vol. 38 No. 6 (2026): Vol. 38 Issue No 6, 2026

Copyright (c) 2026 Jadhav Ramchander, Ramdas Lakavath, Ravi Guguloth

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Synthesis, Characterisation of Substituted 2-[4-Methyl-6-(1-phenyl-1H-[1,2,3]triazol-4-ylmethoxy)pyridin-3-yl]benzothiazole: Evaluation of their Cytotoxic, Antimicrobial and Molecular Docking Studies

https://doi.org/10.14233/ajchem.2026.35534
Lakavath Ramdas
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
Jadhav Ramchander
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0003-3472-2581
Ravi Guguloth
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India

Corresponding Author(s) : Jadhav Ramchander

ramorgchemou@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 6 (2026): Vol. 38 Issue No 6, 2026

Abstract

A series of newly synthesised substituted 2-[4-methyl-6-(1-phenyl-1H-[1,2,3]triazol-4-ylmethoxy)pyridin-3-yl]benzothiazole derivatives (7a-l) were synthesised via click chemistry and characterised using 1H and 13C NMR, mass and IR spectral techniques. The cytotoxic activity of compounds 7a-l was evaluated against MCF-7, PC-3 and HeLa cancer cell lines at concentrations of 5 and 10 µM. Several compounds, notably 7b, 7g, 7j and 7k, exhibited significant cytotoxic effects compared to other compounds. The synthesised benzothiazole-1,2,3-triazoles hybrid derivatives (7a-l) were also evaluated for in vitro antibacterial activity against six different bacterial species. Compounds 7b, 7c, 7e, 7h and 7i exhibited more bacterial potent compared to other compounds. The antifungal activity of compounds 7a-l was assessed at 100 µg/mL against four fungal strains. Compounds 7b, 7c, 7e, 7h and 7i demonstrated significant activity compared to other compounds, indicating potential as effective antifungal agents. Docking investigations were conducted sequentially to analyse binding interactions targeting ERK2 (PDB ID: 4ZXT) and MAPK1. Among the tested compounds 7e, 7f, 7k and 7l exhibited favourable binding energies -8.9 to -9.0 kcal/mol, indicating potential strong interactions with the target proteins.

Keywords

Anticancer activity Antimicrobial activity Molecular docking studies 1,2,3-Triazole Benzothiazole derivatives
(1)
Ramdas, L.; Ramchander, J.; Guguloth, R. Synthesis, Characterisation of Substituted 2-[4-Methyl-6-(1-Phenyl-1H-[1,2,3]triazol-4-ylmethoxy)pyridin-3-yl]benzothiazole: Evaluation of Their Cytotoxic, Antimicrobial and Molecular Docking Studies. ajc 2026, 38, 1393-1402.
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