Issue

Vol. 38 No. 5 (2026): Vol 38, Issue 5, 2026

Copyright (c) 2026 Sarojini Nayak

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

In vitro Antioxidant and Antidiabetic Activity of Solvent Extracts from Aerial Parts of Polygonum plebeium R. Br.

https://doi.org/10.14233/ajchem.2026.35374
Sarojini Nayak
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar-751003, India; Department of Pharmacology, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, India
https://orcid.org/0009-0008-2724-7990
Durga Madhab Kar
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Kalinga Nagar, Bhubaneswar-751003, India
https://orcid.org/0000-0002-9397-3391
N. Saroj Kumar Choudhury
Pharmacy Wing, SCB Medical College, Cuttack-753007, India
https://orcid.org/0009-0008-0130-9233
Manoj Kumar Dalai
Department of Pharma Chemistry, Kanak Manjari Institute of Pharmaceutical Sciences, Rourkela-769015, India
https://orcid.org/0000-0003-4587-8995

Corresponding Author(s) : Sarojini Nayak

nayak.sarojini88@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 5 (2026): Vol 38, Issue 5, 2026

Abstract

This study investigated the aerial parts of Polygonum plebeium for their phytochemical composition, antioxidant potential, in vitro cytotoxicity and glucose uptake activity in yeast cells. Different solvent extracts, namely petroleum ether, chloroform, ethyl acetate, ethanol and aqueous, were evaluated. Antioxidant activity was assessed using DPPH, hydrogen peroxide scavenging and reducing power assays. HPLC analysis of the ethanol extract indicated the presence of several bioactive constituents with distinct retention times. Cytotoxicity studies on human pancreatic Min6 cells showed values of 59 ± 0.84% and 79 ± 0.78% for ethanol and ethyl acetate extracts, respectively, at 800 µg/mL. Among all tested extracts, the ethanol extract demonstrated the strongest antioxidant and antidiabetic potential. These findings suggest that the aerial parts of P. plebeium possess promising hypoglycemic activity and may serve as a potential natural source for diabetes management.

Keywords

Phytochemical In vitro Antioxidant Cytotoxicity Antidiabetic
(1)
Nayak, S.; Kar, D. M.; Choudhury, N. S. K.; Dalai, M. K. In Vitro Antioxidant and Antidiabetic Activity of Solvent Extracts from Aerial Parts of Polygonum Plebeium R. Br. ajc 2026, 38, 1317-1323.
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. B.B. Duncan, D.J. Magliano and E.J. Boyko, Nephrol. Dialysis Transplant., 41, 7 (2026); https://doi.org/10.1093/ndt/gfaf177
  2. K. Wagh, A. Kirpich and G. Chowell, J. Clin. Med., 14, 3364 (2025); https://doi.org/10.3390/jcm14103364
  3. S. Bastaki, Int. J. Diabetes Metab., 13, 111 (2005); https://doi.org/10.1159/000497580
  4. S. Nayak, D.M. Kar and N.S.K. Choudhury, World J. Pharm. Sci. Res., 3, 307 (2024); https://doi.org/10.5281/zenodo.14576685
  5. J.F. Alarcon‐Aguilar, R. Roman‐Ramos, J.L. Flores‐Saenz and F. Aguirre‐Garcia, Phytother. Res., 16, 383 (2002); https://doi.org/10.1002/ptr.914
  6. A. Ramachandran, Indian J. Med. Res., 140, 579 (2014).
  7. M. Khalid, M.H. Alqarni, A. Alsayari, A.I. Foudah, T.M. Aljarba, M. Mukim, M.A. Alamri, S.S. Abullais and S. Wahab, Plants, 11, 562 (2022); https://doi.org/10.3390/plants11040562
  8. M.R. Bhandari, N. Jong-Anurakkun, G. Hong and J. Kawabata, Food Chem., 106, 247 (2008); https://doi.org/10.1016/j.foodchem.2007.05.077.
  9. M. Jung, M. Park, H.C. Lee, Y.H. Kang, E.S. Kang and S.K. Kim, Curr. Med. Chem., 13, 1203 (2006); https://doi.org/10.2174/092986706776360860
  10. F.J. Alarcon-Aguilara, R. Roman-Ramos, S. Perez-Gutierrez, A. Aguilar-Contreras, C.C. Contreras-Weber and J.L. Flores-Saenz, J. Ethnopharmacol., 61, 101 (1998); https://doi.org/10.1016/S0378-8741(98)00020-8
  11. F. Alam, Z. Shafique, S.T. Amjad and M.H.H. Bin Asad, Phytother. Res., 33, 41 (2019); https://doi.org/10.1002/ptr.6211
  12. R.K. AL-Ishaq, M. Abotaleb, P. Kubatka, K. Kajo and D. Büsselberg, Biomolecules, 9, 430 (2019); https://doi.org/10.3390/biom9090430
  13. N.F. Shamsudin, Q.U. Ahmed, S. Mahmood, S.A.A. Shah, M.N. Sarian, M.M.A.K. Khattak, A. Khatib, A.S.M. Sabere, Y.M. Yusoff and J. Latip, Int. J. Mol. Sci., 23, 12605 (2022); https://doi.org/10.3390/ijms232012605
  14. D. Aryal, S. Joshi, N.K. Thapa, P. Chaudhary, S. Basaula, U. Joshi, D. Bhandari, H.M. Rogers, S. Bhattarai, K.R. Sharma, B.P. Regmi and N. Parajuli, Food Sci. Nutr., 12, 3025 (2024); https://doi.org/10.1002/fsn3.3983
  15. M. Saleem, N. Shazmeen, M. Nazir, N. Riaz, G. Zengin, H.M. Ataullah, Q.-ul-Ain, F. Nisar, M. Mukhtar and M.I. Tousif, Chem. Biodiversity, 18, e2100706 (2021); https://doi.org/10.1002/cbdv.202100706
  16. P.C.H. Hollman, J.H.M. de Vries, S.D. van Leeuwen, M.J.B. Mengelers and M.B. Katan, Am. J. Clin. Nutr., 62, 1276 (1995); https://doi.org/10.1093/ajcn/62.6.1276
  17. H. Alinezhad, A. Azimi, M. Zare, M.A. Ebrahimzadeh, S. Eslami, S.F. Nabavi and S.M. Nabavi, Int. J. Food Prop., 16, 1169 (2013); https://doi.org/10.1080/10942912.2011.578319
  18. O. Kwon, P. Eck, S. Chen, C.P. Corpe, J.H. Lee, M. Kruhlak and M. Levine, FASEB J., 21, 366 (2007); https://doi.org/10.1096/fj.06-6620com
  19. S. Kreft, M. Knapp and I. Kreft, J. Agric. Food Chem., 47, 4649 (1999); https://doi.org/10.1021/jf990186p
  20. S. Nayak, D.M. Kar, S.K. Choudhury and M.K. Dalai, Int. J. Pharm. Investig., 14, 273 (2024); https://doi.org/10.5530/ijpi.14.2.35
  21. S. Nayak, D.M. Kar, S.K. Choudhury and M.K. Dalai, Int. J. Pharm. Sci. Res., 16, 1014 (2025); https://doi.org/10.13040/IJPSR.0975-8232.16(4).1014-27
  22. K. Wolfe, X. Wu and R.H. Liu, J. Agric. Food Chem., 51, 609 (2003); https://doi.org/10.1021/jf020782a
  23. A.A. Ordonez, J.D. Gomez, A.A. Vattuone and M. Lsla, Food Chem., 97, 452 (2006); https://doi.org/10.1016/j.foodchem.2005.05.024
  24. M.N. Shahzad, S. Ahmad, M.I. Tousif, I. Ahmad, H. Rao, B. Ahmad and A. Basit, PLoS One, 17, e0266094 (2022); https://doi.org/10.1371/journal.pone.0266094
  25. A. Basit, S. Ahmad, K.R. Khan, A. Naeem, M. Usman, I. Ahmed and M.N. Shahzad, J. Ethnopharmacol., 287, 114942 (2022); https://doi.org/10.1016/j.jep.2021.114942
  26. P. Ethalsha and A.M. Retna, Int. J. Pharm. Pharm. Sci. Res., 5, 3490 (2014).
  27. C.D. Fernando and P. Soysa, MethodsX, 2, 283 (2015); https://doi.org/10.1016/j.mex.2015.05.001
  28. I. Ouerghemmi, I.B. Rebey, F.Z. Rahali, S. Bourgou, L. Pistelli, R. Ksouri and M.S. Tounsi, J. Food Drug Anal., 25, 350 (2017); https://doi.org/10.1016/j.jfda.2016.04.001
  29. N. Anupama, N G. Madhumitha, Int. J. Pharm. Tech. Res., 8, 206 (2015).
  30. G. Madhumitha and A.M. Saral, Asian J. Chem., 21, 2471 (2009).
  31. X.F. Yue, X. Shang, Z.J. Zhang and Y.N. Zhang, J. Food Drug Anal, 25, 327 (2017); https://doi.org/10.1016/j.jfda.2016.10.010
  32. M. Kong, K. Xie, M. Lv, J. Li, J. Yao, K. Yan, X. Wu, Y. Xu and D. Ye, Biomed. Pharmacother., 133, 110975 (2021); https://doi.org/10.1016/j.biopha.2020.110975
  33. C. Sun, C. Zhao, E.C. Guven, P. Paoli, J. Simal-Gandara, K.M. Ramkumar, S. Wang, F. Buleu, A. Pah, V. Turi, G. Damian, S. Dragan, M. Tomas, W. Khan, M. Wang, D. Delmas, M.P. Portillo, P. Dar, L. Chen and J. Xiao, Food Front., 1, 18 (2020); https://doi.org/10.1002/fft2.15
  34. R.K. AL-Ishaq, M. Abotaleb, P. Kubatka, K. Kajo and D. Büsselberg, Büsselberg Biomolecules, 9, 430 (2019); https://doi.org/10.3390/biom9090430
  35. S.B. Patil, S.S. Takalikar, M.M. Joglekar, V.S. Haldavnekar and A.U. Arvindekar, Br. J. Nutr., 110, 1434 (2013); https://doi.org/10.1017/S0007114513000627
  36. P. Poprac, K. Jomova, M. Simunkova, V. Kollar, C.J. Rhodes and M. Valko, Trends Pharmacol. Sci., 38, 592 (2017); https://doi.org/10.1016/j.tips.2017.04.005
  37. N. Ahmad, A. Rab and N. Ahmad, J. Photochem. Photobiol. B, 154, 51 (2016); https://doi.org/10.1016/j.jphotobiol.2015.11.015
  38. F.J. Martins, C.A. Caneschi, J.L.F. Vieira, W. Barbosa and N.R.B. Raposo, J. Photochem. Photobiol. B, 161, 34 (2016); https://doi.org/10.1016/j.jphotobiol.2016.05.012
  39. D. Karakaş, F. Ari and E. Ulukaya, Turk. J. Biol., 41, 919 (2017); https://doi.org/10.3906/biy-1703-104
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download
PDF
Statistic
Read Counter : 1 Download : 0
PlumX