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Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Copyright (c) 2025 Babu Pejjai, M. Varalakshmi, P. Sreevani, K. Jamuna, Reddi Mohan Naidu Kalla

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Polymers and Functionalized Polymer Catalysts in Organic Synthesis: A Mini Review

https://doi.org/10.14233/ajchem.2025.34302
Babu Pejjai
Department of Physics, Sri Venkateswara College of Engineering, Tirupati-517507, India
https://orcid.org/0000-0001-5768-9433
M. Varalakshmi
Department of Biological & Chemical Sciences, Mohan Babu University, Sree Vidyanikethan, Tirupati-517102, India
https://orcid.org/0000-0001-6638-6813
P. Sreevani
Department of Environmental Sciences, S.V. Arts College (Autonomous), TTD, Tirupati-517502, India
https://orcid.org/0009-0003-6463-2525
K. Jamuna
Department of Chemistry, S.V. Arts College (Autonomous), TTD, Tirupati-517502, India
https://orcid.org/0009-0007-1611-9590
Reddi Mohan Naidu Kalla
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India
https://orcid.org/0000-0001-7689-2242

Corresponding Author(s) : Babu Pejjai

pdmj.babu@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Abstract

Polymeric materials, especially poly(ethylene glycol) (PEG)-based systems, play an essential role in biomedical applications due to their biocompatibility and tunable surface properties, which improve blood compatibility and reduce biofouling. Beyond biomedical uses, PEG and PEG-supported catalysts have become valuable in organic synthesis because of their hydrophilicity, broad solubility, low toxicity and ease of functionalization, aligning well with green chemistry principles. This review summarizes key PEG-assisted synthetic methodologies for organophosphorus compounds including dialkyl/aryl phosphonates, α-amino phosphonates and α-hydroxy phosphonates as well as PEG-catalyzed routes for diverse heterocyclic frameworks. These include coumarins, acylals, indazole-triones, dihydropyrimidinones, oxadiazoles, thiadiazoles, pyrroles, bis(indolyl)alkanes, bis(pyrazolyl)methanes and xanthenes. PEG-based protocols typically offer mild conditions, shorter reaction times, high yields and simplified purification. Overall, incorporating Brønsted or Lewis acidic moieties into PEG matrices provides efficient, recyclable and environmentally benign catalytic systems that support sustainable organic synthesis and combinatorial chemistry.

Keywords

Liquid polymers Polymer supported catalyst Phosphonates Heterocyclic compounds
(1)
Pejjai, B.; Varalakshmi, M.; Sreevani, P.; Jamuna, K.; Kalla, R. M. N. Polymers and Functionalized Polymer Catalysts in Organic Synthesis: A Mini Review. ajc 2025, 37, 2963-2971.
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