A New Dihydronaphthoquinone from the Flowers of Rosa rugosa and Its Cytotoxicities

Wei Dong; Yue-De Wang; Kun Zhou; Bing-Kun Ji; Yin-Ke Li; Min Zhou; Qiu-Fen Hu; Xue-Mei Gao; Yan-Qing Ye

doi:10.14233/ajchem.2015.18733

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

Issue Published : June 22, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Dihydronaphthoquinone from the Flowers of Rosa rugosa and Its Cytotoxicities

https://doi.org/10.14233/ajchem.2015.18733

Wei Dong

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yue-De Wang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Kun Zhou

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Bing-Kun Ji

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yin-Ke Li

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Min Zhou

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Qiu-Fen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Xue-Mei Gao

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yan-Qing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Corresponding Author(s) : Yan-Qing Ye

huqiufena@aliyun.com

Asian Journal of Chemistry, Vol. 27 No. 10 (2015): Vol 27 Issue 10
Article Published : June 23, 2015

Abstract

A new dihydronaphthoquinone, rugosaquinone A (1) was isolated from the flowers of Rosa rugosa. Its structure was elucidated by spectroscopic methods, including extensive 1D NMR and 2D NMR experiments. Compound 1 was tested for its cytotoxicity against five human tumor cell lines, NB4, A549, SHSY5Y, PC3 and MCF7 and it showed potential cytotoxicity against NB4 and SHSY5Y cell lines with IC₅₀ values of 4.2 and 2.8 μM, respectively.

Keywords

Rosa rugosa Dihydronaphthoquinone Rugosaquinone A Cytotoxicity

Dong, W., Wang, Y.-D., Zhou, K., Ji, B.-K., Li, Y.-K., Zhou, M., … Ye, Y.-Q. (2015). A New Dihydronaphthoquinone from the Flowers of Rosa rugosa and Its Cytotoxicities. Asian Journal of Chemistry, 27(10), 3917–3918. https://doi.org/10.14233/ajchem.2015.18733

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References

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References

S.M. Gault and P.M. Synge, The Dictionary of Roses in Colour, Ebury Press, London (1971).

J.L. Lu, China Flowers & Horticulture, 11, 26 (2012).

L. Putian and Y. Jiang, Flora of China, Chinese Science Press, Beijing (1977).

S. Ochir, B. Park, M. Nishizawa, T. Kanazawa, M. Funaki and T. Yamagishi, J. Nat. Med., 64, 383 (2010); doi:10.1007/s11418-010-0418-5.

Y. Hashidoko, S. Tahara and J. Mizutani, Phytochemistry, 32, 387 (1993); doi:10.1016/S0031-9422(00)95000-3.

Y. Hashidoko, Phytochemistry, 43, 535 (1996); doi:10.1016/0031-9422(96)00287-7.

H.J. An, I.-T. Kim, H.-J. Park, H.-M. Kim, J.-H. Choi and K.-T. Lee, Int. Immunopharmacol., 11, 504 (2011); doi:10.1016/j.intimp.2011.01.002.

Y. Zhang, Q. Hu, X. Gao, L. Yang, L. Shu and Y. Shen, Heterocycles, 85, 1925 (2012); doi:10.3987/COM-12-12505.

Q.F. Hu, B. Zhou, J.M. Huang, Z.Y. Jiang, X.Z. Huang, L.Y. Yang, X.M. Gao, G.Y. Yang and C.T. Che, J. Nat. Prod., 76, 1866 (2013); doi:10.1021/np4004068.

X.M. Gao, L.D. Shu, L.Y. Yang, Y.Q. Shen, Y.J. Zhang and Q.F. Hu, Bull. Korean Chem. Soc., 34, 246 (2013); doi:10.5012/bkcs.2013.34.1.246.

L.Y. Yang, J.H. Yao, L.D. Shu, Y.Q. Shen, X.M. Gao and Q.F. Hu, Asian J. Chem., 25, 8355 (2013); doi:10.14233/ajchem.2013.14743.

K. Takemoto, S. Kamisuki, P.T. Chia, I. Kuriyama, Y. Mizushina and F. Sugawara, J. Nat. Prod., 77, 1992 (2014); doi:10.1021/np500175j.

Q.F. Hu, B. Zhou, X.M. Gao, L.Y. Yang, L.D. Shu, Y.Q. Shen, G.P. Li, C.T. Che and G.Y. Yang, J. Nat. Prod., 75, 1909 (2012); doi:10.1021/np300395m.

Y.P. Li, Y.C. Yang, Y.K. Li, Z.Y. Jiang, X.Z. Huang, W.G. Wang, X.M. Gao and Q.F. Hu, Fitoterapia, 95, 214 (2014); doi:10.1016/j.fitote.2014.03.026.

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X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.

Q.F. Hu, B. Zhou, Y.Q. Ye, Z.Y. Jiang, X.Z. Huang, Y.K. Li, G. Du, G.Y. Yang and X.M. Gao, J. Nat. Prod., 76, 1854 (2013); doi:10.1021/np400379u.

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

A New Dihydronaphthoquinone from the Flowers of Rosa rugosa and Its Cytotoxicities

Corresponding Author(s) : Yan-Qing Ye

Abstract

Keywords

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