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Vol. 38 No. 2 (2026): Vol 38 Issue 2, 2026

Copyright (c) 2026 Dr. Janardhana Nayak

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Synthesis, Antimicrobial and DFT Studies of 1,3,4-Oxadiazole Linked Quinoline Carbaldehyde Derivatives

https://doi.org/10.14233/ajchem.2026.35047
Janardhana Nayak
Department of Chemistry, NMAM Institute of Technology, Nitte (Deemed to be University), Nitte-574110, India
https://orcid.org/0000-0002-3010-9547
Jyothi Kudva
Department of Chemistry, St. Joseph Engineering College (Affiliated to Visvesvaraya Technological University, Belagavi), Mangaluru-575028, India
https://orcid.org/0000-0002-2055-4460

Corresponding Author(s) : Janardhana Nayak

jnayak@nitte.edu.in

Asian Journal of Chemistry, Vol. 38 No. 2 (2026): Vol 38 Issue 2, 2026

Abstract

A novel series of oxadiazole‑linked quinoline derivatives was synthesized and evaluated for antimicrobial activity and electronic properties. The synthetic pathway involved the preparation of 4‑substituted benzohydrazides, subsequent cyclization to yield 5‑(4‑substituted phenyl)‑1,3,4‑oxadiazole‑2‑thiols, and their coupling with 6/8‑substituted‑2‑chloroquinoline‑3‑carbaldehydes to obtain the target compounds viz. 2-((5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl)thio)-6/8-substituted quinoline-3-carbaldehydes (7a-l) in moderate to good yields. Antibacterial activity was assessed against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, while antifungal activity was evaluated against Candida albicans using minimum inhibitory concentration (MIC) methods. Most compounds exhibited promising antimicrobial activity. Notably, compounds 7g and 7k, bearing p‑nitro phenyl substitution on the oxadiazole ring and chloro substitution on the quinoline nucleus, showed superior antibacterial and antifungal activities comparable to standard drugs.

Keywords

Oxadiazole–quinoline hybrids Antimicrobial activity Density functional theory HOMO-LUMO analysis
(1)
Nayak, J.; Kudva, J. Synthesis, Antimicrobial and DFT Studies of 1,3,4-Oxadiazole Linked Quinoline Carbaldehyde Derivatives. ajc 2026, 38, 417-424.
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