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Vol. 34 No. 9 (2022): Vol 34 Issue 9

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Synthesis, Characterization and Hypoglycemic Efficacy of Isonicotinohydrazide Phenoxy Quinolines: An in silico Studies

https://doi.org/10.14233/ajchem.2022.23814
N. Lohitha
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India *Corresponding author: E-mail: kvpsvijayakumar@gmail.com
V. Vijayakumar
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

Corresponding Author(s) : V. Vijayakumar

kvpsvijayakumar@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 9 (2022): Vol 34 Issue 9

Abstract

Prevention of α-amylase and β-glucosidase to reduce the postprandial blood sugar levels and delays dextrose absorption, the natural inhibitors provide an interesting approach to manage hyperglycemia with type 2 diabetes. The α-amylase and β-glucosidase are important therapeutic targets for type II diabetes. The isonicotinohydrazide phenoxy quinolines (5a-l) were synthesized and characterized by mass, 1H & 13C NMR. The characterized compounds are investigated for their in silico anti-hyperglycemic efficacy and the compounds shown effective to moderate inhibition against α-amylase and β-glucosidase enzymes. A molecular modelling study was performed for all the synthesized compounds to find the binding interaction of 5a-l with the α-amylase and β-glucosidase.

Keywords

Isonicotinohydrazide phenoxy quinolines Antidiabetics in silico Docking α-Amylase β-Glucosidase
Lohitha, N., & Vijayakumar, V. (2022). Synthesis, Characterization and Hypoglycemic Efficacy of Isonicotinohydrazide Phenoxy Quinolines: An in silico Studies. Asian Journal of Chemistry, 34(9), 2241–2246. https://doi.org/10.14233/ajchem.2022.23814
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