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Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

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An Expedient Synthesis of 2-Aryl-substituted 2,3-Dihydroquinazolin-4(1H)-ones in Low Transition Temperature Mixture (LTTM) containing SnCl2 and L-Proline

https://doi.org/10.14233/ajchem.2022.23759
V.M. Desai
Department of Chemistry, Smt. Kasturbai Walchand College, Sangli-416416, India ; PG Department of Chemistry, P.D.V.P. College, Tasgaon-416312, India
A.T. Birajdar
PG Department of Chemistry, P.D.V.P. College, Tasgaon-416312, India
S.P. Patil
PG Department of Chemistry, P.D.V.P. College, Tasgaon-416312, India
R.V. Kupwade
Department of Chemistry, Smt. Kasturbai Walchand College, Sangli-416416, India
M.B. Deshmukh
Department of Chemistry, Shivaji University, Kolhapur-416004, India
S.S. Patil
PG Department of Chemistry, P.D.V.P. College, Tasgaon-416312, India

Asian Journal of Chemistry, Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

Abstract

2,3-Dihydroquinazolin-4(1H)-ones were synthesized in excellent yield in a prepared low transition temperature mixture (LTTM) containing SnCl2 and L-proline using either direct one-pot two-component cyclocondensation of anthranilamide and aldehydes or one-pot three-component cyclocondensation of isatoic anhydride, ammonium acetate and aldehydes. The prepared LTTM is a green solvent, inexpensive, non-toxic and serves a dual function as reusable catalyst and solvent with excellent reaction endorsing medium. The current protocol has several advantages including an easy work up, shorter reaction time, high yield with a higher atom economy and maximum reaction efficiency with excellent green chemistry metrics.

Keywords

Low transition temperature mixture Green chemistry Quinazolinone 2-Aryl-substituted 2,3-dihydroquinazolin-4(1H)-ones
Desai, V., Birajdar, A., Patil, S., Kupwade, R., Deshmukh, M., & Patil, S. (2022). An Expedient Synthesis of 2-Aryl-substituted 2,3-Dihydroquinazolin-4(1H)-ones in Low Transition Temperature Mixture (LTTM) containing SnCl2 and L-Proline. Asian Journal of Chemistry, 34(7), 1886–1892. https://doi.org/10.14233/ajchem.2022.23759
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