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Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

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C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines

https://doi.org/10.14233/ajchem.2022.23769
Laimujam Sidartha Singh
Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, India
Arup K. Kabi
Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, India
Ragini Sengupta
Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, India
Anupam Roy
Department of Physics, Techno India University, Kolkata-700091, India
Abhishek Sahoo
Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, India
Indranil Saha
Department of Physics, Techno India University, Kolkata-700091, India
Chandi C. Malakar
Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, India

Corresponding Author(s) : Chandi C. Malakar

chdeepm@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 7 (2022): Vol 34 Issue 7, 2022

Abstract

This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature. On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The developed strategy proceeds via C-N bond formation.

Keywords

C-N bond formation Amidation Iodine-catalyzed C1-synthon 1,3,5-Triazines
Sidartha Singh, L., K. Kabi, A., Sengupta, R., Roy, A., Sahoo, A., Saha, I., & C. Malakar, C. (2022). C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines. Asian Journal of Chemistry, 34(7), 1841–1847. https://doi.org/10.14233/ajchem.2022.23769
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