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Vol. 34 No. 6 (2022): Vol 34 Issue 6

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Metabolite Profiling and Antimicrobial Activity of Aloe greatheadii var. Davyana against Bacterial Illness

https://doi.org/10.14233/ajchem.2022.23643
Denga Nthai
Department of Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, Ga-Rankuwa, South Africa
Vuyisile S. Thibane
Department of Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, Ga-Rankuwa, South Africa
Sechene S. Gololo
Department of Department of Biochemistry and Biotechnology, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, Ga-Rankuwa, South Africa

Corresponding Author(s) : Sechene S. Gololo

Stanley.gololo@smu.ac.za

Asian Journal of Chemistry, Vol. 34 No. 6 (2022): Vol 34 Issue 6

Abstract

The aim of the study was to profile the metabolite content of Aloe greatheadii and investigate their antibacterial potential against illness causing bacteria. The metabolite profile of A. greatheadii was determined and the antibacterial activity tested against Gram-positive and Gram-negative bacteria. The metabolite profile resolved on TLC plates indicated an almost similar pattern of bands for majority of the separated compounds. The results on the maximum absorption wavelength of extracts from all locations ranged between 240 and 320 nm. The most susceptible bacteria for the treatment by samples from all the provinces was the Gram-positive E. faecalis with MIC values ranging from 0.54 to 0.067 mg/mL. It was interesting to note that susceptibility of the tested bacteria to treatment by the plant extracts was not specific to either Gram-positive or Gram-negative bacteria.

Keywords

Aloe greatheadii Antibacterial activity Commensal bacteria Natural products
Nthai, D., S. Thibane, V., & S. Gololo, S. (2022). Metabolite Profiling and Antimicrobial Activity of Aloe greatheadii var. Davyana against Bacterial Illness. Asian Journal of Chemistry, 34(6), 1597–1602. https://doi.org/10.14233/ajchem.2022.23643
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References
  1. H. Human and S.W. Nicolson, Phytochemistry, 67, 1486 (2006); https://doi.org/10.1016/j.phytochem.2006.05.023
  2. L. Botes, F. van der Westhuizen and D. Loots, Molecules, 13, 2169 (2008); https://doi.org/10.3390/molecules13092169
  3. M.H. Radha and N.P. Laxmipriya, J. Tradit. Complement. Med., 5, 21 (2015); https://doi.org/10.1016/j.jtcme.2014.10.006
  4. O.M. Grace, M.S.J. Simmonds, G.F. Smith and A.E. van Wyk, J. Ethnopharmacol., 119, 604 (2008); https://doi.org/10.1016/j.jep.2008.07.002
  5. P. Masoko and J.N. Eloff, Afr. J. Biotechnol., 4, 1425 (2005).
  6. M.N. Alekshun and S.B. Levy, Biochem. Pharmacol., 71, 893 (2006); https://doi.org/10.1016/j.bcp.2005.12.040
  7. A.C. Anderson, D. Jonas, I. Huber, L. Karygianni, J. Wölber, E. Hellwig, N. Arweiler, K. Vach, A. Wittmer and A. Al-Ahmad, Front. Microbiol., 6, 1534 (2016); https://doi.org/10.3389/fmicb.2015.01534
  8. A. Leimbach, J. Hacker and U. Dobrindt, Eds.: U. Dobrindt, J. Hacker and C. Svanborg, E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity, In: Between Pathogenicity and Commensalism Current Topics in Microbiology and Immunology. Springer: Berlin, Heidelberg, pp. 3-32 (2013); https://doi.org/10.1007/82_2012_303
  9. S. Ryu, P. Song, C. Seo, H. Cheong and Y. Park, Int. J. Mol. Sci., 15, 8753 (2014); https://doi.org/10.3390/ijms15058753
  10. J.B. Lyczak, C.L. Cannon and G.B. Pier, Microbes Infect., 2, 1051 (2000); https://doi.org/10.1016/S1286-4579(00)01259-4
  11. H. Wagner and S. Bladt, Plant Drug Analysis: A Thin Layer Chromatography, Springer-Verlag: Berlin Heidelberg, Ed. 2 (1996).
  12. S.K. Banu and L. Cathrine, Int. J. Adv. Res. Chem. Sci., 2, 25 (2015).
  13. J.N. Eloff, J. Ethnopharmacol., 60, 1 (1998); https://doi.org/10.1016/S0378-8741(97)00123-2
  14. J.H. Doughari, Eds: V. Rao, Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents. InTechOpen (2012).
  15. K.L. Metlen, E.T. Aschehoug and R.M. Callaway, Plant Cell Environ., 32, 641 (2009); https://doi.org/10.1111/j.1365-3040.2008.01910.x
  16. T. Isah, Biol. Res., 52, 39 (2019); https://doi.org/10.1186/s40659-019-0246-3
  17. L.-Z. Lin, J. Harnly, R.-W. Zhang, X.-E. Fan and H.-J. Chen, J. Agric. Food Chem., 60, 544 (2012); https://doi.org/10.1021/jf204612t
  18. O. Taofiq, A. González-Paramás, M. Barreiro and I. Ferreira, Molecules, 22, 281 (2017); https://doi.org/10.3390/molecules22020281
  19. P.J. Herald and P.M. Davidson, J. Food Sci., 48, 1378 (1983); https://doi.org/10.1111/j.1365-2621.1983.tb09243.x
  20. S. Thiruchenduran, K.U. Maheswari, T.N.V.K.V. Prasad, B. Rajeswari and W.J. Suneetha, J. Pharmacogn. Phytochem., 6, 411 (2017).
  21. S.S. Gololo, D. Nthai and M.A. Mogale, Asian J. Chem., 31, 1830 (2019); https://doi.org/10.14233/ajchem.2019.22019
  22. S.S. Gololo, N.S. Mapfumari, L.J. Shai, L. Sethoga, O. Mutendela, F.M. Muganza and A.M. Mogale, Eds.: A.A. Mahdi, M. Abid and A.A. Khan, Disparities in the Phytochemical Constituents of the Leaf Samples of Senna italica (Mill) Collected from Four Different Locations; In: Phytochemistry and Pharmacology of Medicinal Herbs, Lenin Media Private Limited: Delhi, India (2017).
  23. A.H. Delcour, Proteins Proteomics, 1794, 808 (2009); https://doi.org/10.1016/j.bbapap.2008.11.005
  24. U. Choi and C.-R. Lee, Front. Microbiol., 10, 953 (2019); https://doi.org/10.3389/fmicb.2019.00953
  25. M.Y. Mushtaq, Y.H. Choi, R. Verpoorte and E.G. Wilson, Phytochem. Anal., 25, 291 (2014); https://doi.org/10.1002/pca.2505
  26. S.T. Carpes, R. Begnini, S.M. Alencar and M.L. Masson, Cienc. Agrotec., 31, 1818 (2007); https://doi.org/10.1590/S1413-70542007000600032
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