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Synthesis, Characterization and Antibacterial Study of Some Transition Metal Complexes with Novel Schiff Base having 1,3,4-Thiadiazole Moiety
Corresponding Author(s) : Apeksha W. Walke
Asian Journal of Chemistry,
Vol. 34 No. 6 (2022): Vol 34 Issue 6
Abstract
Some transition metal ions [Zr(IV), Co(II), Cu(II), Cr(III), Ag(I), Pd(II)] complexes were synthesized by reacting anisaldehyde, thiosemicarbazide and 2-(4-hydroxybenzylideneamino)benzoic acid to form (4-[2{5-[(4-methoxy-benzylidene)amino][1,3,4]thiadiazole-2-yl}phenylimino)methyl]phenol ligand. Schiff base ligand and its metal complexes were characterized by elemental analysis, IR, UV-visible, NMR (1H NMR, 13C NMR), thermal analysis, molar conductance, magnetic susceptibility and antimicrobial study. Zone of inhibition as well as MIC has been evaluated against E. coli (MTCC443), S. aureus (MTCC1688), P. aeruginosa (MTCC96), C. albicans (MTCC227), A. niger (MTCC82) organisms comparing with standard antimicrobial and antifungal drugs. TGA/DTA of the synthesized metal complexes shows the thermal stability and non-spontaneous nature of decomposition. It also shows multi-step degradation behaviour and final weight loss with respect to the formation of metal oxide and residue.
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References
Y. Hu, C.-Y. Li, X.-M. Wang, Y.-H. Yang and H.-L. Zhu, Chem. Rev., 114, 5572 (2014); https://doi.org/10.1021/cr400131u
L.H. Abdel-Rahman, M.S. Adam, A.M. Abu-Dief, H.E.-S. Ahmed and A. Nafady, Molecules, 25, 5089 (2020);
https://doi.org/10.3390/molecules25215089
N. Jeniffer, C. Ascencio, P. Karlos, G. Mariellen, L. Danielle, V. Helito, M. Sydnei, N. Celso and R. Fernanda, Front. Pharmacol., 11, 591570 (2020); https://doi.org/10.338/gphar.22.591570
H. Goodman, L. Mei and T.L. Gianetti, Front. Chem., 7, 365 (2019); https://doi.org/10.3389/fchem.2019.00365
J.-W. Zheng and L. Ma, Chin. Chem. Lett., 27, 283 (2016); https://doi.org/10.1016/j.cclet.2015.11.015
A. Ibrar, I. Khan and N. Abbas, Arch. Pharm., 346, 423 (2013); https://doi.org/10.1002/ardp.201300041
B.B. Zmejkovski, N.Ð. Pantelic and G.N. Kaluderovic, Inorg. Chim. Acta, 534, 120797 (2022); https://doi.org/10.1016/j.ica.2022.120797
M.S. More, P.G. Joshi, Y.K. Mishra and P.K. Khanna, Mater. Today Chem., 14, 100195 (2019); https://doi.org/10.1016/j.mtchem.2019.100195
M.J. Kareem, A.A.S. Al-Hamdani, V.Y. Jirjees, M.E. Khan, A.W. Allaf and W. Al Zoubi, J. Phys. Org. Chem., 34, e4156 (2020); https://doi.org/10.1002/poc.4156
B. Ejelonu, IOSR J. Appl. Chem., 9, 12 (2016); https://doi.org/10.9790/5736-0909021215
T. Sucipto, W. Setyarini, F. Martak and D. Raharjo, Rasayan J. Chem., 14, 672 (2021); https://doi.org/10.31788/RJC.2021.1425826
K.D. Serges, P.K.S. Laure, N.M. Legentil, K. Norbert and S.L.W. Ngnokam, J. Pharm. Biol. Sci., 8, 23 (2020); https://doi.org/10.18231/j.jpbs.2020.004
F.K. Ommenya, E.A. Nyawade, D.M. Andala and J. Kinyua, J. Chem., 2020, Article ID 1745236 (2020); https://doi.org/10.1155/2020/1745236
B.N. Sanglik, B.K. Cavusoglu, U.A. Cevik, D. Osmaniye, S. Levent, Y. Ozkay and Z.A. Kaplancikli, RCS Med. Chem., 11, 1063 (2020); https://doi.org/10.1039/D0MD00150C