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Fluoroquinolones Metal Complexes as Potent Antibacterial Agents: A Review

https://doi.org/10.14233/ajchem.2022.23600
Savita Khatri
Department of Chemistry, University Institute of Engineering & Technology, Maharshi Dayanand University, Rohtak-124001, India
Manoj Kumar
Department of Chemistry, University Institute of Engineering & Technology, Maharshi Dayanand University, Rohtak-124001, India
Harkesh Sehrawat
Department of Chemistry, University Institute of Engineering & Technology, Maharshi Dayanand University, Rohtak-124001, India
S.P. Khatkar
Department of Chemistry, Maharshi Dayanand University, Rohtak-124001, India
V.B. Taxak
Department of Chemistry, Maharshi Dayanand University, Rohtak-124001, India
Rajesh Kumar
Department of Chemistry, University Institute of Engineering & Technology, Maharshi Dayanand University, Rohtak-124001, India

Corresponding Author(s) : Rajesh Kumar

lather_rajesh@yahoo.com

Asian Journal of Chemistry, Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

Abstract

In this review article, a brief discussion of fluoroquinolones (FQs) and their tendency to form metal complexes is presented. The effect of FQs-M complexes on disease causing microorganisms is also summarized. The antibacterial activity of various metal complexes of various fluoroquinolones [norfloxacin (NOR), ciprofloxacin (CIP), levofloxacin (LEVO), ofloxacin (OFL), gemifloxacin (GEMI), gatifloxacin (GATI), moxifloxacin (MOX), enrofloxacin (ENRO), sparfloxacin (SPRX)] is reviewed by comparing zone of inhibition and MIC values of metal complexes. It is found to be either corresponding with the parent fluoroquinolone or in some cases their respective metal complexes exhibit stronger antibacterial activity. New approach towards synthesis of FQ-metal complexes has led to formation of compounds with the anticancer and antiviral activity.

Keywords

Fluoroquinolones Fluoroquinolones Metal chelates Metal chelates IR spectra IR spectra Antibacterial activities Antibacterial activities
Khatri, S., Kumar, M., Sehrawat, H., Khatkar, S., Taxak, V., & Kumar, R. (2022). Fluoroquinolones Metal Complexes as Potent Antibacterial Agents: A Review. Asian Journal of Chemistry, 34(5), 1055–1065. https://doi.org/10.14233/ajchem.2022.23600
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