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Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

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Mechanochemical Synthesis of Biologically Active Transition Metal Complexes of 1H-4,4,6-Trimethyl-3,4-dihydropyrimidine-2-thione

https://doi.org/10.14233/ajchem.2022.23605
Pooja Sethi
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, India
Rajshree Khare
Department of Chemistry, M.P.N. College, Mullana, Ambala-133207, India
Renuka Choudhary
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, India
Simrat Kaur
Department of Chemistry, Mata Gujri College, Fatehgarh Sahib-140407, India

Corresponding Author(s) : Pooja Sethi

pooja.amb80@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

Abstract

A new series of metal complexes using 1H-4,4,6-trimethyl-3,4-dihydro-2-pyrimidinethione (HTMPT) ligand were synthesized mechanochemically and also evaluated for antibacterial and DNA photocleavage potential. Complexes of 1H-4,4,6-trimethyl-3,4-dihydro-2-pyrimidinethione (HTMPT) [M(tmpt)2(H2O)n] (M = Cu2+, Mn2+, Ni2+, Co2+; n = 2 and M = Zn2+, Cd2+, Pd2+; n = 0) were synthesized in 1:2 metal ligand ratio. All the metal complexes were characterized by 1H NMR, FTIR, UV-vis, ESI-mass spectrometry, molar conductivity, magnetic and thermal measurements. 1H NMR and IR results showed that the coordination occurs via N and S forming four-membered cyclic ring. Mass spectrum showed the formation of 1:2 metals to ligand stoichiometry. The antibacterial activity of synthesized compounds was evaluated by agar well diffusion method. All the synthesized compounds were evaluated for their DNA nicking activity and found most of metal complexes exhibited good DNA photocleavage activities.

Keywords

Transition metal(II) complexes 2-Pyrimidinethione Biological activity Thermal study
Sethi, P., Khare, R., Choudhary, R., & Kaur, S. (2022). Mechanochemical Synthesis of Biologically Active Transition Metal Complexes of 1H-4,4,6-Trimethyl-3,4-dihydropyrimidine-2-thione. Asian Journal of Chemistry, 34(5), 1157–1164. https://doi.org/10.14233/ajchem.2022.23605
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