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Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

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Synthesis of Novel Organic Compounds from Cyanuric Chloride Containing 1-(4-(7-Chloroquinolin-4-ylamino)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one Chalcone for Biological Applications

https://doi.org/10.14233/ajchem.2022.23662
Revathy Selvaraj
PG and Research Department of Chemistry, Government Arts College, Thiruvannamalai-606603, India ; R & D Centre, Bharathiar University, Coimbatore-641046, India
J. Suresh
PG and Research Department of Chemistry, Government Arts College, Thiruvannamalai-606603, India ; R & D Centre, Bharathiar University, Coimbatore-641046, India
E. Vakees
PG and Research Department of Chemistry, Government Arts College, Thiruvannamalai-606603, India
A. Arun
PG and Research Department of Chemistry, Government Arts College, Thiruvannamalai-606603, India

Corresponding Author(s) : A. Arun

aruna2075@yahoo.co.in

Asian Journal of Chemistry, Vol. 34 No. 5 (2022): Vol 34 Issue 5, 2022

Abstract

This article reported the synthesis of triazine having quinoline chalcone moiety and its derivatives. Cyanuric chloride, 1-(4-(7-chloroquinolin-4-ylamino)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (KKC), aniline, 4-nitro aniline and 1-naphthol used for the synthesis. Triazine having chlorine atom was periodically replaced by the above materials to synthesize the desired product. Synthesized triazine based organic molecules were characterized using elemental analysis, FT-IR, 1H NMR and UV-visible spectroscopic techniques. Antibacterial activity of synthesized compounds was found on Gram-positive and Gram-negative bacteria by utilizing MIC method, most of the synthesized compound shows higher activity on Gram-positive bacteria Staphylococcus aureus with the value of 7.81 (mg/mL) than Gram-negative Escherichia coli. The presence of quinoline chalcone moiety and electron rich species responsible for higher antibacterial activity of the compounds on the tested bacteria.

Keywords

Quinoline Chalcone Triazine Synthesis Antimicrobial activity
Selvaraj, R., Suresh, J., Vakees, E., & Arun, A. (2022). Synthesis of Novel Organic Compounds from Cyanuric Chloride Containing 1-(4-(7-Chloroquinolin-4-ylamino)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one Chalcone for Biological Applications. Asian Journal of Chemistry, 34(5), 1139–1144. https://doi.org/10.14233/ajchem.2022.23662
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