Issue

Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

Copyright (c) 2022 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Green Synthesis of Purslane Seeds-Selenium Nanoparticles and Evaluate its Cytokines Inhibitor in Lead Acetate Induced Toxicity in Rats

https://doi.org/10.14233/ajchem.2022.23362
Mohamed S. Naser Eldin
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Marwa T. Eissa
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Mai T. Mansour
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Hanan A. Abdelmonem
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Amira A. Ahmed
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Norhan O. Ali
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Mai A. Abd El-haleem
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Sayed A. Sayed
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Sara M. Emara
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Mohamed M. Yousif
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Mohamed A. Ibrahim
Department of Radiology and Medical Imaging, Faculty of Applied Medical science, October 6th University, October 6th City, Egypt
Mohamed A. Salem
Department of Organic Chemistry, Faculty of Pharmacy, October 6th University, October 6th City, Egypt
Fakher M. Ahmed
Department of Organic Chemistry, Faculty of Pharmacy, October 6th University, October 6th City, Egypt
Mohammed A. Hussein
Department of Biochemistry, Faculty of Applied Medical Science, October 6th University, October 6th City, Egypt

Corresponding Author(s) : Mohammed A. Hussein

prof.husseinma@o6u.edu.eg

Asian Journal of Chemistry, Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

Abstract

Lead is a heavy metal that produces toxicity in both humans and animals due to oxidative stress. The aim of this study was to synthesize through green channel and evaluate hepatoprotective effect of purslane seeds-selenium nanoparticles (PS-Se NPs) against lead acetate-induced liver toxicity. The PS-Se NPs were made and their particle size and zeta potential were measured. In addition, the IC50 of SP-Se NPs against the HepG-2 liver cancer cell line as well as and LD50 in rats were determined. The PS-Se NPs had a mean particle size of around 54.70 ± 4.55 nm, a negative zeta potential of +17.25 and the observed shape of the nanoparticle was spherical. Also, the IC50 of PS-Se NPs against HepG-2 liver carcinoma cell line is 92.66 μg/mL and the LD50 is 1695 mg/kg b.w. Daily oral administration of PS-Se NPs at concentrations of 33.9 and 84.75 mg/kg b.w. for 30 days to rats treated with lead acetate (0.6 mg/kg b.w.) resulted in significant improvements in ALT, AST, ALP, TNF-α, Bcl-2, P53 and MDA. In contrast, oral administration of PS-Se NPs increased the levels of SOD, GPx and GSH in the liver tissue of lead acetate-treated rats. Furthermore, PS-Se NPs almost normalized these effects in histoarchitecture and ultrasound scanning examination of liver tissue. The PS-Se NPs have protective activity against lead acetate-induced liver tissue injury in rats, according to the biochemical, histological and ultrasound scanning findings.

Keywords

Purslane seeds PS-SeNPs Lead acetate Liver tissue toxicity Cytokine storm
S. Naser Eldin, M., T. Eissa, M., T. Mansour, M., A. Abdelmonem, H., A. Ahmed, A., O. Ali, N., … A. Hussein, M. (2022). Green Synthesis of Purslane Seeds-Selenium Nanoparticles and Evaluate its Cytokines Inhibitor in Lead Acetate Induced Toxicity in Rats. Asian Journal of Chemistry, 34(4), 894–900. https://doi.org/10.14233/ajchem.2022.23362
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. M. Andjelkovic, A. Buha Djordjevic, E. Antonijevic, B. Antonijevic, M. Stanic, J. Kotur-Stevuljevic, V. Spasojevic-Kalimanovska, M. Jovanovic, N. Boricic, D. Wallace and Z. Bulat, Int. J. Environ. Res. Public Health, 16, 274 (2019); https://doi.org/10.3390/ijerph16020274
  2. V. Manoj Kumar, A.K. Henley, C.J. Nelson, O. Indumati, Y. Prabhakara Rao, S. Rajanna and B. Rajanna, Environ. Sci. Pollut. Res. Int., 24, 1544 (2017); https://doi.org/10.1007/s11356-016-7923-3
  3. F. Atif, S. Yousuf and S.K. Agrawal, Brain Res., 1265, 128 (2009); https://doi.org/10.1016/j.brainres.2008.12.077
  4. J.M. Basgen and C. Sobin, Toxicol. Lett., 225, 48 (2014); https://doi.org/10.1016/j.toxlet.2013.11.031
  5. K.K. Bokara, E. Brown, R. McCormick, P.R. Yallapragada, S. Rajanna and R. Bettaiya, Biometals, 21, 9 (2008); https://doi.org/10.1007/s10534-007-9088-5
  6. S.J.S. Flora, G. Flora and G. Saxena, Eds.: J.S. Casas and J. Sordo, Environmental Occurrence, Health Effects and Management of Lead Poisoning, In: Lead, Elsevier: Amsterdam, pp. 158–228 (2006).
  7. G. McGregor and H. Biesalski, Curr. Opin. Clin. Nutr. Metab. Care, 9, 697 (2006); https://doi.org/10.1097/01.mco.0000247478.79779.8f
  8. B.A. Aldahmash and D.M. El-Nagar, Pak. J. Zool., 46, 1425 (2014).
  9. M. Pratap and P. Indira, Int. J. Pharm. Biol. Sci., 5, 888 (2014).
  10. M. Baranowska and A. Bartoszek, Postepy Hig. Med. Dosw., 70, 1460 (2016); https://doi.org/10.5604/17322693.1227896
  11. Z. Hu, J. Lin, J. Chen, T. Cai, L. Xia, Y. Liu, X. Song and Z. He, Front. Pharmacol., 12, 630834 (2021); https://doi.org/10.3389/fphar.2021.630834
  12. S. Galiniak, D. Aebisher and D. Bartusik-Aebisher, Acta Biochim. Pol., 66, 13 (2019); https://doi.org/10.18388/abp.2018_2749
  13. J.M. Breuss, A.G. Atanasov and P. Uhrin, Int. J. Mol. Sci., 20, 1523 (2019); https://doi.org/10.3390/ijms20071523
  14. Z. Akdemir, C. Kahraman, I.I. Tatli, E.K. Akkol, I. Süntar and H. Keles, J. Ethnopharmacol., 136, 436 (2011); https://doi.org/10.1016/j.jep.2010.05.059
  15. I. Higuera-Ciapara, L. Félix-Valenzuela and F.M. Goycoolea, Crit. Rev. Food Sci. Nutr., 46, 185 (2006); https://doi.org/10.1080/10408690590957188
  16. V. Aeri, U. Kaushik and S.R. Mir, Pharmacogn. Rev., 9, 12 (2015); https://doi.org/10.4103/0973 7847.156314
  17. A. Gheflati, E. Adelnia and A. Nadjarzadeh, Phytother. Res., 33, 1501 (2019); https://doi.org/10.1002/ptr.6342
  18. M.A. Ebrahimzad, S.F. Nabavi and S.M. Nabavi, Pak. J. Biol. Sci., 12, 957 (2009); https://doi.org/10.3923/pjbs.2009.957.963
  19. J.K. da Silva, P.J. Sousa, E.H. Andrade and J.G. Maia, J. Agric. Food Chem., 55, 9422 (2007); https://doi.org/10.1021/jf071928e
  20. K. Décordé, A. Agne, D. Lacan, J. Ramos, G. Fouret, E. Ventura, C. Feillet-Coudray, J.-P. Cristol and J.-M. Rouanet, J. Agric. Food Chem., 57, 6461 (2009); https://doi.org/10.1021/jf900504g
  21. S.H. Han, B.S. Yang and H.J. Kim, Taehan Kanho Hakhoe Chi, 33, 839 (2003); https://doi.org/10.4040/jkan.2003.33.6.839
  22. M. Anusha, V. Prabhakaran, B.P. Kumari, M. Venkateswarlu, S.S. Taj and D. Ranganayakulu, Indian J. Pharmacol., 43, 563 (2011); https://doi.org/10.4103/0253-7613.84973
  23. M.A. Hussein and S.M. Abdelgwade, Malays. J. Nutr., 16, 161 (2010).
  24. M.A. Hussein, J. Med. Food, 16, 246 (2013); https://doi.org/10.1089/jmf.2012.0183
  25. H.A. Elgizawy, M.A. Hussein and E. Abdel-Sattar, Pharm. Biol., 57, 485 (2019); https://doi.org/10.1080/13880209.2019.1643378
  26. L.A. Barakat and R.H. Mahmoud, N. Am. J. Med. Sci., 3, 411 (2011); https://doi.org/10.4297/najms.2011.3411
  27. P. Abal, M.C. Louzao, A. Antelo, M. Alvarez, E. Cagide, N. Vilariño, M.R. Vieytes and L.M. Botana, Toxins, 9, 75 (2017); https://doi.org/10.3390/toxins9030075
  28. J. Xu, L. Lian, C. Wu, X. Wang, W. Fu and J. Xu, Food Chem. Toxicol., 46, 1488 (2008); https://doi.org/10.1016/j.fct.2007.12.016
  29. D. Otto-Slusarczyk, W. Graboñ and M. Mielczarek-Puta, Postepy Hig. Med. Dosw., 70, 219 (2016); https://doi.org/10.5604/17322693.1197373
  30. S. Vimalraj, Gene, 754, 144855 (2020); https://doi.org/10.1016/j.gene.2020.144855
  31. K. Ma, H. Zhang and Z. Baloch, Int. J. Mol. Sci., 17, 733 (2016); https://doi.org/10.3390/ijms17050733
  32. T. Vervliet, J.B. Parys and G. Bultynck, Oncogene, 35, 5079 (2016); https://doi.org/10.1038/onc.2016.31
  33. A. Schmidt, S. Bekeschus, K. Jarick, S. Hasse, T. von Woedtke and K. Wende, Oxid. Med. Cell. Longev., 2019, 7017363 (2019); https://doi.org/10.1155/2019/7017363
  34. A. Kumar, Khushboo, R. Pandey and B. Sharma, Biol. Trace Elem. Res., 196, 654 (2020); https://doi.org/10.1007/s12011-019-01957-3
  35. C. Rocha-Santos, F.F. Bastos, R.F. Dantas, R.A. Hauser-Davis, L.C. Rodrigues, V.L.F. Cunha Bastos and J. Cunha Bastos, Ecotoxicol. Environ. Saf., 163, 604 (2018); https://doi.org/10.1016/j.ecoenv.2018.06.089
  36. A.M. Domijan, J. Ralic, S. Radic-Brkanac, L. Rumora and T. •anicGrubisic, Biomed. Chromatogr., 29, 41 (2015); https://doi.org/10.1002/bmc.3361
  37. N. Jiang, L. Lu, T. Wang, L. Zhang, W. Xin and F. Fu, Toxicol. Mech. Methods, 20, 69 (2010); https://doi.org/10.3109/15376510903575782
  38. M.S. Attia, H.M. Mohammed, M.G. Attia, M.A.A.E. Hamid and E.A. Shoeriabah, J. Periodontol., 90, 281 (2019); https://doi.org/10.1002/JPER.17-0469
  39. SPSS, 2012. (SPSS 15), Inc., Chicago, IL, USA (2012).
  40. M. Sathishkumar, K. Sneha, S.W. Won, C.W. Cho, S. Kim and Y.S. Yun, Colloids Surf. B Biointerfaces, 73, 332 (2009); https://doi.org/10.1016/j.colsurfb.2009.06.005
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0