Copyright (c) 2022 AJC
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Design and Synthesis of Novel Bis-Morpholinotriazine Analogs and their Antibacterial, Antifungal and Antioxidant Studies
Corresponding Author(s) : A.K.D. Bhavani
Asian Journal of Chemistry,
Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022
Abstract
A series of novel analogues of bis-morpholino-1,3,5-triazine derivatives are synthesized from cyanuric chloride as starting precursor. The products are characterized by spectral data and their biological evaluation against microbials are reported. Antioxidant properties of these compounds are also studied.
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- Y.-Z. Xiong, F.-E. Chen, J. Balzarini, E. De Clercq and C. Pannecouque, Eur. J. Med. Chem., 43, 1230 (2008); https://doi.org/10.1016/j.ejmech.2007.08.001
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References
E. Peterson and P. Kaur, Front. Microbiol., 9, 2928 (2018); https://doi.org/10.3389/fmicb.2018.02928
S. Santajit and N. Indrawattana, BioMed. Res. Int., 2016, 2475067 (2016); https://doi.org/10.1155/2016/2475067
A.M. Fuentefria, B. Pippi, D.F. Dalla Lana, K.K. Donato and S.F. de Andrade, Lett. Appl. Microbiol., 66, 2 (2018); https://doi.org/10.1111/lam.12820
E.A. Friedman, Behind the Headlines: 10 Million Deaths From Antimicrobial Resistance by 2050 (or Not?), February, 2020; https://oneill.law.georgetown.edu/behind-the-headlines-10-million antimicrobial-deaths-by-2050-or-not
A. Dhainaut, G. Regnier, A. Tizot, A. Pierre, S. Leonce, N. Guilbaud, L. Kraus-Berthier and G. Atassi, J. Med. Chem., 39, 4099 (1996); https://doi.org/10.1021/jm960361i
S.W. Kim, S.C. Shim, B.-J. Jung and H.-K. Shim, Polymer, 43, 4297 (2002); https://doi.org/10.1016/S0032-3861(02)00252-5
R. Bai, S. Li, Y. Zou, C. Pan, P. Xie, B. Kong, X. Zhou and R. Zhang, Liq. Cryst., 28, 1873 (2001); https://doi.org/10.1080/02678290110086514
J.-W. Kang, D.-S. Lee, H.-D. Park, J.W. Kim, W.-I. Jeong, Y.-S. Park, S.-H. Lee, K. Go, J.-S. Lee and J.-J. Kim, Org. Electron., 9, 452 (2008); https://doi.org/10.1016/j.orgel.2008.02.002
R.N. Butler, A.M. Fahy, A. Fox, J.C. Stephens, P. McArdle, D. Cunningham and A.G. Ryder, Tetrahedron Lett., 47, 1721 (2006); https://doi.org/10.1016/j.tetlet.2006.01.052
N. Karade, P. Thorat and B. Bhong, Synlett, 24, 2061 (2013); https://doi.org/10.1055/s-0033 1339495
M. Kitamura, F. Kawasaki, K. Ogawa, S. Nakanishi, H. Tanaka, K. Yamada and M. Kunishima, J. Org. Chem., 79, 3709 (2014); https://doi.org/10.1021/jo500376m
D.H. Patel, K.H. Chikhalia, N.K. Shah, D.P. Patel, P.B. Kaswala and V.M. Buha, J. Enzyme Inhib. Med. Chem., 25, 121 (2010); https://doi.org/10.3109/14756360903027956
A. Solankee, K. Kapadia, Ana Ciriæ, M. Sokovic, I. Doytchinova and A. Geronikaki, Eur. J. Med. Chem., 45, 510 (2010); https://doi.org/10.1016/j.ejmech.2009.10.037
K. Srinivas, U. Srinivas, K. Bhanuprakash, K. Harakishore, U.S.N. Murthy and V. Jayathirtha Rao, Eur. J. Med. Chem., 41, 1240 (2006); https://doi.org/10.1016/j.ejmech.2006.05.013
C. Borsari, D. Rageot, F. Beaufils, T. Bohnacker, E. Keles, I. Buslov, A. Melone, A.M. Sele, P. Hebeisen, D. Fabbro, P. Hillmann and M.P. Wymann, ACS Med. Chem. Lett., 10, 1473 (2019); https://doi.org/10.1021/acsmedchemlett.9b00333
A.M. Venkatesan, C.M. Dehnhardt, E. Delos Santos, Z. Chen, O. Dos Santos, S. Ayral-Kaloustian, G. Khafizova, N. Brooijmans, R. Mallon, I. Hollander, L. Feldberg, J. Lucas, K. Yu, J. Gibbons, R.T. Abraham, I. Chaudhary and T.S. Mansour, J. Med. Chem., 53, 2636 (2010); https://doi.org/10.1021/jm901830p
A. Baliani, G.J. Bueno, M.L. Stewart, V. Yardley, R. Brun, M.P. Barrett and I.H. Gilbert, J. Med. Chem., 48, 5570 (2005); https://doi.org/10.1021/jm050177+
S. Melato, D. Prosperi, P. Coghi, N. Basilico and D. Monti, ChemMedChem, 3, 873 (2008); https://doi.org/10.1002/cmdc.200700344
Y.-Z. Xiong, F.-E. Chen, J. Balzarini, E. De Clercq and C. Pannecouque, Eur. J. Med. Chem., 43, 1230 (2008); https://doi.org/10.1016/j.ejmech.2007.08.001
N. Sunduru, L. Gupta, V. Chaturvedi, R. Dwivedi, S. Sinha and P.M. Chauhan, Eur. J. Med. Chem., 45, 3335 (2010); https://doi.org/10.1016/j.ejmech.2010.04.017
A.J. Huh and Y.J. Kwon, J. Control. Release, 156, 128 (2011); https://doi.org/10.1016/j.jconrel.2011.07.002
S. Shaikh, N. Nazam, S.M.D. Rizvi, K. Ahmad, M.H. Baig, E.J. Lee and I. Choi, Int. J. Mol. Sci., 20, 2468 (2019); https://doi.org/10.3390/ijms20102468
B. Song, H. Zhang, H. Wang, S. Yang, L. Jin, D. Hu, L. Pang and W. Xue, J. Agric. Food Chem., 53, 7886 (2005); https://doi.org/10.1021/jf051050w
S. Song, L. Zhou, D. Li, D. Tang, J. Li and W. Jiang, Nat. Prod. Res. Dev., 16, 157 (2004).
N. Cotelle, J.-L. Bernier, J.-P. Catteau, J. Pommery, J.-C. Wallet and E.M. Gaydou, Free Radic. Biol. Med., 20, 35 (1996); https://doi.org/10.1016/0891-5849(95)02014-4