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Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

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One-Pot Synthesis and Characterization of 3,4-Dihydropyrimidin-2(1H)-one Derivatives using Sulphonated Reduced Graphene Oxide Nanoparticles via Biginelli Cyclocondensation and its Cytotoxic Studies

https://doi.org/10.14233/ajchem.2022.23543
M. Bhaskara Rao
Department of Basic Science & Humanities, Miracle Educational Society Group of Institutions, Bhogapuram-535216, India
B. Venkateswara Rao
Department of Organic Chemistry, Andhra University, Visakhapatnam-530003, India

Corresponding Author(s) : M. Bhaskara Rao

bachi.chemistry1987@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

Abstract

A facile one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (4a-h) was performed in the presence of sulphonated reduced graphene oxide nanoparticles (SrGO NPs), using various substituted aromatic aldehydes (1a-h), β-keto ester (2) and urea (3). Methanol solvent mediated the reaction, under refluxing conditions. The synthesized SrGO NPs were characterized using XRD, SEM-EDS and Raman spectroscopic methods. The structural moieties of the organic compounds were confirmed by 1H NMR, 13C NMR, FTIR and Mass spectroscopic techniques. The in vitro anticancer activity of the synthesized derivatives (4a-h) was investigated using MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay as per American Type Culture Collection protocol. The cytotoxic studies were conducted against MCF-7, SKNSH human cells, using doxorubicin as the standard. Majority of the derivatives have exhibited superior anticancer activity.

Keywords

One-pot synthesis Dihydropyrimidones Anticancer activity
Bhaskara Rao, M., & Venkateswara Rao, B. (2022). One-Pot Synthesis and Characterization of 3,4-Dihydropyrimidin-2(1H)-one Derivatives using Sulphonated Reduced Graphene Oxide Nanoparticles via Biginelli Cyclocondensation and its Cytotoxic Studies. Asian Journal of Chemistry, 34(3), 627–634. https://doi.org/10.14233/ajchem.2022.23543
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