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Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

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Design and Synthesis of Novel Piperazine (2-Chloroethyl)-1-nitrosourea Analogues as Anticancer Agents

https://doi.org/10.14233/ajchem.2022.23552
Sudharshanacharyulu Sowmithri
Department of Chemistry, Koneru Lakshmaiah Education Foundation (KLEF), Green Fields,Vaddeswaram, Guntur-522502, India
J.V. Shanmukha Kumar
Department of Chemistry, Koneru Lakshmaiah Education Foundation (KLEF), Green Fields,Vaddeswaram, Guntur-522502, India
Palla Mahesh
Therapiva Pvt Ltd, IDA Pashamylaram, Hyderabad-502307, India
T. Krishnamohan
Department of Chemistry, Koneru Lakshmaiah Education Foundation (KLEF), Green Fields, Vaddeswaram, Guntur-522502, India

Corresponding Author(s) : Sudharshanacharyulu Sowmithri

sudharshanacs@drreddys.com

Asian Journal of Chemistry, Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

Abstract

A series of piperazine (2-chloroethyl)-1-nitrosourea analogues (6a-h) have been designed, synthesized, characterized and screened for anticancer activity against five human cancer cell lines viz. human colorectal cancer (HCT-116 and HCT-15), human colon cancer (Colo-205), human breast cancer (MCF-7) and leukaemia (Molt-4). Among the screened compounds, compound 6f exhibits potent activity against HCT-116 cell line with an IC50 of 1.0 μM, which regarded as promising drug candidate for the development of anticancer agents.

Keywords

Anticancer agents Anticancer agents Human breast cancer Human breast cancer Human colon cancer Human colon cancer Leukaemia Leukaemia Piperazine Piperazine (2-Chloroethyl)-1-nitrosourea (2-Chloroethyl)-1-nitrosourea
Sowmithri, S., Shanmukha Kumar, J., Mahesh, P., & Krishnamohan, T. (2022). Design and Synthesis of Novel Piperazine (2-Chloroethyl)-1-nitrosourea Analogues as Anticancer Agents. Asian Journal of Chemistry, 34(3), 591–596. https://doi.org/10.14233/ajchem.2022.23552
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