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Vol. 34 No. 2 (2022): Vol 34 Issue 2

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Acid Catalyzed Multicomponent One-Pot Synthesis of New Quinazolinone based Unsymmetrical C-N Linked Bis Heterocycles

https://doi.org/10.14233/ajchem.2022.23619
Nagamani Rayala
Department of Chemistry, Osmania University, Hyderabad-500007, India
Sumathi Vodnala
Department of Chemistry, University College of Science, Osmania University, Saifabad, Hyderabad-500004, India
Supriya Kamsani
Department of Chemistry, Osmania University, Hyderabad-500007, India
A.K.D. Bhavani
Department of Chemistry, Osmania University, Hyderabad-500007, India
Nagaraju Myakala
Department of Chemistry, Osmania University, Hyderabad-500007, India
Kotaiah Kandula
Department of Chemistry, Osmania University, Hyderabad-500007, India
Sucheta Mudiganti
Department of Chemistry, Maturi Venkata Subba Rao Engineering College, Hyderabad-500004, India

Corresponding Author(s) : A.K.D. Bhavani

durgabhavani237@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 2 (2022): Vol 34 Issue 2

Abstract

A novel series of unsymmetrical C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons have been synthesized in an acid promoted one pot multicomponent reaction. A blend of 6-aminoquinazolin-4-(3H)-one, aromatic aldehydes and cyclohexane-1,3-dione in a simple and efficient condensation-cyclization reaction using hydrochloric acid in catalytic amount as catalyst afforded unsymmetrical bis hybrids in good to excellent yields. Multiheterocyclic hybrid compounds were also synthesized using heterocyclic ring containing aldehyde in three component reaction. The synthesized quinazolinone-acridindione hybrids were characterized using spectroscopic techniques such as a IR, 1H NMR, 13C NMR, ESI-mass and HRMS.

Keywords

Decahydroacridinedione Unsymmetrical bis heterocycle 6-Aminoquinazolin-4(3H)-one Cyclohexanedione Acid catalyst
Rayala, N., Vodnala, S., Kamsani, S., Bhavani, A., Myakala, N., Kandula, K., & Mudiganti, S. (2022). Acid Catalyzed Multicomponent One-Pot Synthesis of New Quinazolinone based Unsymmetrical C-N Linked Bis Heterocycles. Asian Journal of Chemistry, 34(2), 432–436. https://doi.org/10.14233/ajchem.2022.23619
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