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Vol. 34 No. 12 (2022): Vol 34 Issue 12, 2022

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Sodium-Carboxymethylcellulose/Polyphenol-Gossypol-Carboxymethylcellulose Copolymer Films for Ocular Drug Delivery: Preparation and Physico-Chemical Properties

https://doi.org/10.14233/ajchem.2022.23912
Yunusov Khaydar Ergashovich
Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Abdulla Kadyri Street, Tashkent 100128, Uzbekistan
Sarymsakov Abdushkur Abdukhalilovich
Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Abdulla Kadyri Street, Tashkent 100128, Uzbekistan
Shukurov Akobirkhon Ibodullo O`g`li
Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Abdulla Kadyri Street, Tashkent 100128, Uzbekistan
Todjiyev Jamoliddin Nasiriddinovich
Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Abdulla Kadyri Street, Tashkent 100128, Uzbekistan
Atakhanov Abdumutalib Abdupatto Ugli
Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Abdulla Kadyri Street, Tashkent 100128, Uzbekistan
Guohua Jiang
2 School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang
Sergey O. Solomevich
Research Institute for Physical Chemical Problems of the Belarusian State University, Minsk 220030, Belarus

Corresponding Author(s) : Yunusov Khaydar Ergashovich

polymer@academy.uz; silver4727@yahoo.com

Asian Journal of Chemistry, Vol. 34 No. 12 (2022): Vol 34 Issue 12, 2022

Abstract

In present work, the formation of nanostructured antiviral biosoluble ophthalmic drug films composed of sodium carboxymethylcellulose/polyphenol-gossypol-carboxymethylcellulose copolymer is described. The biorelease time and physico-chemical parameters of the ophthalmic drug films were regulated by changes in the degree of substitution and polymerization of sodium carboxymethylcellulose and the pH value of its aqueous solutions. The morphology and size of the antiviral agent embedded in sodium carboxymethylcellulose films were determined by using atomic force microscopy and dynamic light scattering. The UV spectroscopy was used to observe drug release from the polymeric matrix and it was determined that the maximum drug release occurred after 24 h. By regulating the concentration of polyphenol-gossypol-carboxymethylcellulose copolymer antiviral substance in the polymer, the spherical nanoparticles with sizes of 5-24 nm and cubic nanoparticles with sizes of 46-95 nm were formed.

Keywords

Drug delivery Antiviral eye films Sodium carboxymethylcellulose Sodium carboxymethylcellulose Polymer drug mixture film Polymer drug mixture film Release kinetics Release kinetics
Khaydar Ergashovich, Y., Abdushkur Abdukhalilovich, S., Akobirkhon Ibodullo O`g`li, S., Jamoliddin Nasiriddinovich, T., Abdumutalib Abdupatto Ugli, A., Jiang, G., & O. Solomevich, S. (2022). Sodium-Carboxymethylcellulose/Polyphenol-Gossypol-Carboxymethylcellulose Copolymer Films for Ocular Drug Delivery: Preparation and Physico-Chemical Properties. Asian Journal of Chemistry, 34(12), 3085–3092. https://doi.org/10.14233/ajchem.2022.23912
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