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Vol. 34 No. 11 (2022): Vol 34 Issue 11, 2022

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Toxicity, Genotoxicity and Ecotoxicity of Food Colourants Especially Synthetic Dyes and its Metabolites: An in silico Approach

https://doi.org/10.14233/ajchem.2022.23987
Abhijit Kargupta
Department of Basic Science and Humanities, Institute of Engineering & Management, Sector V, Salt Lake Electronics Complex, Kolkata700091, India
Kakoli Dutta
Department of Basic Science and Humanities, Institute of Engineering & Management, Sector V, Salt Lake Electronics Complex, Kolkata700091, India
Dibakar Roychoudhury
Department of Basic Science and Humanities, Institute of Engineering & Management, Sector V, Salt Lake Electronics Complex, Kolkata700091, India
Subhasis Rana
Department of Basic Science and Humanities, University of Engineering & Management, New Town, Action Area-III, Kolkata-700160, India
Soumendra Nath Talapatra
Department of Bio-Science, Seacom Skills University, Kendradangal, Bolpur-731236, India

Corresponding Author(s) : Kakoli Dutta

kakoli.dutta@iemcal.com

Asian Journal of Chemistry, Vol. 34 No. 11 (2022): Vol 34 Issue 11, 2022

Abstract

In present study, in silico study was performed to predict rat oral acute toxicity, hepatoxicity, immunotoxicity, genotoxicity endpoints as well as ecotoxicity of daphnids and fish of different food colourants and its metabolites. A total 13 types of food colourants and 8 metabolites were selected. The prediction of rat oral acute toxicity (LD50) and genotoxicity endpoints, and ecotoxicity (LC50) were performed by using ProTox-II webserver and ECOSAR tool. It was obtained as 81 and 275 mg/Kg for tartrazine and green S as class 3 and rests were between class 4-6 for food colourants and 626 and 1925 mg/Kg for aminopyrazolone and 5-sulphoanthranilic acid as class 4 and rest were between 5-6 for metabolites. All the food colourants were non-hepatotoxic while four compounds were found immuno-toxic. For metabolites, only aminopyrazolone obtained hepatotoxic, but not immuno-toxic. Allura red was carcinogenic and few were mutagenic, but all were non-cytotoxic. For metabolites, few were carcinogenic but non-mutagenic and non-cytotoxic.

Keywords

In silico Predictive toxicity Genotoxicity Ecotoxicity Food colourants
Kargupta, A., Dutta, K., Roychoudhury, D., Rana, S., & Nath Talapatra, S. (2022). Toxicity, Genotoxicity and Ecotoxicity of Food Colourants Especially Synthetic Dyes and its Metabolites: An in silico Approach. Asian Journal of Chemistry, 34(11), 2955–2960. https://doi.org/10.14233/ajchem.2022.23987
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