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Vol. 34 No. 10 (2022): Vol 34 Issue 10, 2022

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An Efficient One Pot Multicomponent Synthesis of Dihydro Pyrazolyl Bisthiazole Derivatives as Potential Anticancer Agents and their Molecular Docking Studies

https://doi.org/10.14233/ajchem.2022.23984
Anjaneyulu Varluvothu
Department of Chemistry, Osmania University, Hyderabad-500007, India
Krishnaiah Vaarla
Department of Chemistry, National Institute of Technology, Warangal-506004, India
Rajesh Kumar Kesharwani
Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj-221505, India
Panaganti Leelavathi
Department of Chemistry, Osmania University, Hyderabad-500007, India

Corresponding Author(s) : Panaganti Leelavathi

leelaou@gmail.com; leelaou@osmania.ac.in

Asian Journal of Chemistry, Vol. 34 No. 10 (2022): Vol 34 Issue 10, 2022

Abstract

A novel series of dihydropyrazolyl bisthiazoles were synthesized through simple reaction conditions via one pot multicomponent reaction of 2-bromo-1-(4-methyl-2-phenyl thiazol-5-yl)ethan-1-one, thiosemicarbazide and chalcones in the presence of sodium hydroxide in ethanol under reflux condition. The reaction generates two potential five membered heterocylic pharmacophores i.e. Hantzsch thiazole and dihydropyrazole in one step through simple operation, in shorter reaction time with high yields. The newly synthesized compounds were well characterized by IR, 1H, 13C NMR and mass spectral data. All the newly synthesized compounds were evaluated for their anticancer activity against human cancer cell lines and calculated their binding energy values with respect to 3ert protein. Some of the compounds exhibited excellent activity against MCF-7 cancer cell line and studied molecular interaction of probable target protein, human estrogen receptor alpha protein (3ert.pdb) using docking simulation.

Keywords

Multicomponent reaction Dihydropyrazolyl bisthiazoles Anticancer activity Molecular docking studies
Varluvothu, A., Vaarla, K., Kumar Kesharwani, R., & Leelavathi, P. (2022). An Efficient One Pot Multicomponent Synthesis of Dihydro Pyrazolyl Bisthiazole Derivatives as Potential Anticancer Agents and their Molecular Docking Studies. Asian Journal of Chemistry, 34(10), 2717–2724. https://doi.org/10.14233/ajchem.2022.23984
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