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Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Copyright (c) 2025 Sanket Kumar Chakravarti, Vibha Sharma, Abhay Nanda Srivastva, Som Shankar Dubey, Netra Pal Singh

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Carboxamide-Based Probe for Highly Selective Detection of Copper Ions: Synthesis, Spectroscopic Analysis, Theoretical Investigations and Catalytic Activity

https://doi.org/10.14233/ajchem.2025.34301
Sanket Kumar Chakravarti
Department of Chemistry, D.D.U. Gorakhpur University, Gorakhpur-273009, India
https://orcid.org/0009-0003-9631-6535
Vibha Sharma
Department of Chemistry, N.A.S. (P.G.) College, Meerut-250003, India
Abhay Nanda Srivastva
University Department of Chemistry, B.R.A. Bihar University, Muzaffarpur-842001, India
https://orcid.org/0000-0003-4712-3924
Som Shankar Dubey
Department of Chemistry, D.D.U. Gorakhpur University, Gorakhpur-273009, India
https://orcid.org/0000-0002-5294-1596
Netra Pal Singh
Department of Chemistry, D.D.U. Gorakhpur University, Gorakhpur-273009, India; Department of Chemistry, Dr. H.S. Gour Vishwavidyalaya, (A Central University), Sagar-470003, India
https://orcid.org/0000-0002-0542-0472

Corresponding Author(s) : Netra Pal Singh

npsmcm.in@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Abstract

A carboxamide based fluorescent probe N2,N6-bis(5-(p-tolyl)thiazol-2-yl)pyridine-2,6-dicarboxamide was synthesized by the condensation reaction between pyridine-2,6-dicarboxylic and amino derivative of thiazole and characterized by FT-IR spectroscopy, 1H NMR, 13C NMR, UV-vis spectroscopy and LC-MS spectral studies. Absorption and fluorescence titrations were used to study the fluorescent. The probe exhibits high selectivity and sensitivity towards Cu2+ ions over a spectrum of metal ions (Cu2+, Co2+, Ni2+, Hg2+, Cr3+, Al3+, Fe2+, Sn2+ and Pb2+). Using Job’s plot measurements, the binding stoichiometry mode of the probe with the Cu2+ ion was estimated to be 2:1. The Benesi-Hildebrand equation yielded a stability constant value of 8.252 × 107 M–2 for the fluorescent probe. It was found that the fluorescent probe’s limit of detection (LOD) for the Cu2+ ion was 0.0242 µM. DFT analyses have also been performed to support the sensing technique. The Cu(II) complex's catalytic activity was assessed using the one-pot azide–alkyne cycloaddition click reaction in water without the use of any supplementary agents.

Keywords

Sensing Catalytic activity Chemosensor Binding constant Carboxamide ligand
(1)
Chakravarti, S. K.; Sharma, V.; Srivastva, A. N.; Dubey, S. S.; Singh, N. P. Carboxamide-Based Probe for Highly Selective Detection of Copper Ions: Synthesis, Spectroscopic Analysis, Theoretical Investigations and Catalytic Activity. ajc 2025, 37, 2291-2297.
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