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Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Copyright (c) 2025 Dr. Lalit Mohan Nainwal, Dr. Poonam Arora, Ms. Vanshika Bansal, Mr. Priyanshu Poonia, Dr. Shwetakshi Sharma, Ms. Pallavi Barik, Ms. Nidhi Tiwari

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Pyrimidine Scaffolds as Versatile Platforms for Therapeutic Potential: A Review

https://doi.org/10.14233/ajchem.2025.34772
Lalit Mohan Nainwal
Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244102, India
https://orcid.org/0000-0001-7482-190X
Poonam Arora
Department of Pharmacognosy and Phytochemistry, SGT College of Pharmacy, SGT University, Gurugram-122505, India
https://orcid.org/0000-0002-4118-8180
Vanshika Bansal
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad-201206, India
Priyanshu Poonia
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad-201206, India
Shwetakshi Sharma
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad-201206, India
https://orcid.org/0000-0001-8881-4276
Pallavi Barik
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad-201206, India
https://orcid.org/0009-0009-6929-1057
Nidhi Tiwari
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad-201206, India
https://orcid.org/0000-0001-5169-8603

Corresponding Author(s) : Lalit Mohan Nainwal

lalit12331@yahoo.com

Asian Journal of Chemistry, Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Abstract

Nitrogen-bearing heterocycles continue to shape modern medicinal chemistry owing to their structural adaptability and capacity to participate in diverse biochemical interactions. Within this class, pyrimidine frameworks have emerged as especially influential, providing a chemically economical core from which varied pharmacological profiles can be engineered. Their modular architecture supports precise functionalization, enabling the design of molecules with activities spanning antiviral, anticancer, anti-inflammatory, antibacterial, antitubercular, antimalarial and neuroactive domains. Recent studies demonstrate that integrating pyrimidine cores with complementary heterocycles particularly thiazole units can substantially enhance target engagement, strengthen metabolic stability and yield more favourable pharmacodynamic profiles. This review summarizes the current progress in the development of pyrimidine-based scaffolds, emphasizing the relationship between structural modification and biological response. The collective findings underscore the continued relevance of pyrimidine chemistry as a driver in the discovery of next-generation therapeutic agents.

Keywords

Fused-pyrimidine derivatives Pharmacophore FDA approved drugs Drug discovery
(1)
Nainwal, L. M.; Arora, P.; Bansal, V.; Poonia, P.; Sharma, S.; Barik, P.; Tiwari, N. Pyrimidine Scaffolds As Versatile Platforms for Therapeutic Potential: A Review. ajc 2025, 37, 2897-2930.
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